Fms-Related tyrosine Kinase 3 (FLT3) antibody (Biotin)

Antigen: Fms-Related tyrosine Kinase 3 (FLT3)

Synonyms: FLK2, STK1, CD135, FLT3

Clonality: Monoclonal (BV10A4H2)

Host: Mouse

Reactivity: Human

Conjugate: Biotin

Application: Flow Cytometry (FACS)

Catalog no.: ABIN179888

Additional Information

Alternative name: CD135

Immunogen: BV-173 pro-B cell line

Isotype: IgG1, kappa chain

Clone: BV10A4H2

Description: CD135 is a 130-160 type III tyrosine kinase receptor expressed on CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML-BC. CD135, also known as FMS-like tyrosine kinase-3, FLT3, STK-1, and Flk-2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc. Distribution: Expressed on CD34 hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. Also expressed on AML, ALL and CML-BC tumor cells Function: Tyrosine kinase growth factor receptor involved in the growth and differentiation of primitive hematopoietic cells Synonyms: FMS-like tyrosine kinase-3, FLT-3, STK-1, Flk-2 Structure: Member of the immunoglobulin supergene family, type 3 tyrosine kinase receptor, 130-160 kD

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is < 0.5 µg per 10 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Purification: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin and unconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Storage: The antibody solution should be stored undiluted at 4°C. Do not freeze.

Research Area: CD Antigens

Restrictions: For Research Use only

Images

anti-Fms-Related tyrosine Kinase 3 (FLT3) antibody (Biotin)