Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) antibody (APC/Cy7)

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C)

Synonyms: BAFFR, CD268, BAFF-R, MGC138235, RGD1560810, TNFRSF13C

Clonality: Monoclonal (11C1)

Host: Mouse

Reactivity: Human

Conjugate: APC,Cy7

Application: Flow Cytometry (FACS)

Catalog no.: ABIN179895

Additional Information

Alternative name: CD268 (BAFF-R| BAFFR)

Immunogen: BAFF-R-L1.2 transfectants

Isotype: IgG1, kappa chain

Clone: 11C1

Description: B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-kappa B activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-kappa B activation. Distribution: Mature B cells, B cell lymphoma, T cell subset Function: Induce B cell proliferation and immunoglobulin secretion, costimulate T cell activation Synonyms: TNFRSF13C, BAFF-R, BAFFR, BR3, BAFF Receptor Structure: Type III transmembrane protein, TNF receptor superfamily, 19 kD

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 µl per million cells or 20 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Purification: The antibody was purified by affinity chromatography, and conjugated with APC/Cy7 under optimal conditions. The solution is free of unconjugated APC/Cy7 and unconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Storage: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Research Area: CD Antigens

Restrictions: For Research Use only

Images

anti-Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) antibody (APC/Cy7)