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Description
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The T7-241 antibody recognizes human BAFF also known as B cell activating factor, tumor necrosis factor ligand superfamily 13B, B lymphocyte stimulator (BLYS), TNF and APOL-related leukocyte expressed ligand 1 (TALL1), and TNF homolog that activates apoptosis, NF-kappaB, and JNK (THANK). BAFF is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. BAFF can be proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homotrimers. The predicted molecular weight of a BAFF monomer is approximately 31 kD. BAFF is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN-gamma and downregulated by PMA/ionomycin treatment. The T7-241 antibody has been shown to be useful for flow cytometry and ELISA. BAFF stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors, BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3). The T7-241 antibody has been shown to be useful for flow cytometry and ELISA. Distribution: Peripheral blood B and T lymphocytes, monocytes, macrophages, dendritic cells. Upregulated by IFN-gamma downregulated by PMA/ionomycin treatment Function: Stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors. Prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3). Synonyms: BAFF, BLYS, TNFSF13b, B cell activating factor, tumor necrosis factor ligand superfamily 13B, B lymphocyte stimulator (BLYS), TNF and APOL-related leukocyte expressed ligand 1 (TALL1), TNF homolog that activates apoptosis, NF-kappaB and JNK (THANK) Structure: Type II transmembrane protein, member of the tumor necrosis factor ligand superfamily. Can be proteolytically cleaved to form soluble protein. Forms homotrimers, predicted molecular weight of monomer approximately 31 kD.
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