Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) antibody (Biotin)

Antigen: Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B)

Synonyms: DTL, BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, TNFSF13B, RGD1561519

Clonality: Monoclonal (T7-241)

Host: Mouse

Reactivity: Human

Conjugate: Biotin

Application: Flow Cytometry (FACS)

Catalog no.: ABIN179905

Additional Information

Alternative name: CD257 (BAFF| BLYS)

Isotype: IgG1, kappa chain

Clone: T7-241

Description: The T7-241 antibody recognizes human BAFF also known as B cell activating factor, tumor necrosis factor ligand superfamily 13B, B lymphocyte stimulator (BLYS), TNF and APOL-related leukocyte expressed ligand 1 (TALL1), and TNF homolog that activates apoptosis, NF-kappaB, and JNK (THANK). BAFF is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. BAFF can be proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homotrimers. The predicted molecular weight of a BAFF monomer is approximately 31 kD. BAFF is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN-gamma and downregulated by PMA/ionomycin treatment. The T7-241 antibody has been shown to be useful for flow cytometry and ELISA. BAFF stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors, BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3). The T7-241 antibody has been shown to be useful for flow cytometry and ELISA. Distribution: Peripheral blood B and T lymphocytes, monocytes, macrophages, dendritic cells. Upregulated by IFN-gamma downregulated by PMA/ionomycin treatment Function: Stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors. Prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3). Synonyms: BAFF, BLYS, TNFSF13b, B cell activating factor, tumor necrosis factor ligand superfamily 13B, B lymphocyte stimulator (BLYS), TNF and APOL-related leukocyte expressed ligand 1 (TALL1), TNF homolog that activates apoptosis, NF-kappaB and JNK (THANK) Structure: Type II transmembrane protein, member of the tumor necrosis factor ligand superfamily. Can be proteolytically cleaved to form soluble protein. Forms homotrimers, predicted molecular weight of monomer approximately 31 kD.

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is < 0.5 µg per 10 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Purification: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin and unconjugated antibody.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Storage: The antibody solution should be stored undiluted at 4°C. Do not freeze.

Restrictions: For Research Use only