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Antibodies
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anti-Endoglin (ENG) antibody (Biotin)
Endoglin (ENG) antibody (Biotin)
| Antigen |
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| Synonyms |
END, ORW, HHT1, ORW1, CD105, FLJ41744, AI528660, AI662476, S-endoglin, Eng, MGC124909, ENG, MGC137842, DKFZp469D0419 |
| Clonality |
Monoclonal (43A3) |
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Host
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Reactivity
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Conjugate
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Application
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| Catalog no. |
ABIN179930 |
| Quantity |
100 µg |
| Price |
Product not available in this region.
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| Shipping to |
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Alternative name
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CD105
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Immunogen
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L-cells transfected with human CD105
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Isotype
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IgG1, kappa chain
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Clone
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43A3
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Description
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CD105 is also known as Endoglin. It is a type I integral membrane homodimer protein with subunits of 90 kD found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on activated monocytes and tissue macrophages. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. CD105 is a component of the TGF-beta receptor system in human umbilical vein endothelial cells and binds TGF-beta1 and beta3 with high affinity but does not bind to TGF-beta2. Distribution: Endothelial cells, activated monocytes/macrophages, bone marrow stromal cells, hematopoietic stem/progenitor cells Function: Modulates cellular response to TGF-ß, involved in vascular development and remodelling Synonyms: Endoglin Structure: Associates with TGF-ß receptor I and II, homodimeric type I integral membrane protein, 90 kD
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Application Notes
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is < 1.0 µg per 10 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
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Purification
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The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin and unconjugated antibody.
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Buffer
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Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
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Storage
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The antibody solution should be stored undiluted at 4°C. Do not freeze.
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Research Area
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CD Antigens
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Restrictions
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For Research Use only
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Alternatives for antigen "Endoglin (ENG)", type "Antibodies"
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Hosts
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Mouse (49), Rabbit (21), Rat (6)
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Reactivities
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Human (60), Mouse (Murine) (11), Horse (Equine) (6), Pig (Porcine) (6), Rat (Rattus) (1)
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Applications
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Flow Cytometry (FACS) (58), Western Blotting (WB) (45), Immunoprecipitation (IP) (20), Immunohistochemistry (Frozen Sections) (IHC (fro)) (14), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (10), Enzyme Immunoassay (EIA) (9), Immunohistochemistry (IHC) (7), ELISA (5), ELISA (Detection) (3), Immunofluorescence (IF) (3)
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Conjugates
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FITC (8), PE (7), APC (2), Biotin (2), Alexa Fluor 488 (1), Alexa Fluor 700 (1), DY647 (1), Dyomics 647 (1), Pacific Blue (1)
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Epitopes
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AA 26-176 (4), Center E395 (1)
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Alternatives 
