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Amyloid B (AA 11-28) antibody
| Antigen | Amyloid B |
| Epitope |
AA 11-28 |
| Clonality | Monoclonal (12B2) |
| Host |
Mouse |
| Reactivity |
Human |
| Application |
Immunohistochemistry (IHC), Western Blotting (WB)
|
| Catalog no. | ABIN180023 |
| Quantity | 50 µg |
| Price | 517.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Alternative name | Amyloid b (11-28) |
| Immunogen | Synthetic peptide for Human Amyloid [11-28] |
| Isotype | IgG1 (Matching secondary antibodies) |
| Clone | 12B2 |
| Description | Alzheimer's disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide(A), a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by beta-secretase and a putative secretase. Increased release of the `longer forms' of A peptide, A42 or A43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alles, or may involve other, still undiscovered, factors, Many researchers theorize that it is this increased release of A42/Abeta 43 which leads to the abnormal deposition of A and the associated neurotoxicity in the brains of affected individuals. |
| Specificity | React with Human Amyloid[1-40], [1-42] and [1-43] |
Application Details
| Application Notes | This antibody can be stained in formalin fixed paraffin embedded tissues after formic acid treatment*1 by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 0.251 ug/ml, however, the dilution rate should be optimized by each laboratories. *1 rinsing by running water after formic acid treatment for 5 minutes following de-paraffin. This antibody can be used for dot blotting in concentration of 2~5 ug /ml. |
| Purification | Antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 0.5 ml distilled water will be added to the product |
| Storage | Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20 |
| Research Area | Alzheimer's Disease |
| Restrictions | For Research Use only |
