Suppressor of Cytokine Signaling 3 (SOCS3) antibody

Antigen: Suppressor of Cytokine Signaling 3 (SOCS3)

Synonyms: SSI-3, socs3, fj09e12, zgc:56537, wu:fj09e12, MGC64393, MGC75749, xsocs3, MGC81248, SOCS-3, cis3, ssi3, atod4, cish3, ssi-3, socs-3, MGC88877, SOCS3

Clonality: Monoclonal (19A5)

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN180043

Additional Information

Alternative name: CIS3/SOCS-3 (19A5)

Immunogen: Synthetic peptide for a C-terminal part of Human CIS3/SOCS-3 (C204)

Isotype: IgG1  (Matching secondary antibodies)

Clone: 19A5

Description: The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein-3 (CIS3/SOCS-3/SSI-3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BF-ER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPO-dependent proliferation and STAT5 activation.

Application Details

Application Notes: This antibody can be used for western blotting in concentration of 1-5 ug/ml. Reference: Yoshimura A. The CIS family: negative regulators of JAK-STAT signaling. Cytokine Growth Factor Rev. 9 (3-4): 1-97-204, 1-998 Sasaki A., Yasukawa H., Shouda T., Kitamura T., Dikic I., and Yoshimura A. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 2-75 (38): 2-9338-47, 2-000

Purification: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1.0 ml distilled water will be added to the product

Storage: Lyophilized product, 5 years at 2 ­ 8 : Solution, 2 years at ­20

Research Area: Transcription Factors

Restrictions: For Research Use only

Images

anti-Suppressor of Cytokine Signaling 3 (SOCS3) antibody