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Antibodies
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anti-8-Oxoguanine DNA Glycosylase (OGG1) antibody
8-Oxoguanine DNA Glycosylase (OGG1) antibody
| Antigen |
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| Synonyms |
HMMH, MUTM, OGH1, HOGG1, OGG1, ogg1, 8-OXOGUANINE-DNA GLYCOSYLASE 1, F8K7.14, F8K7_14, 19.m02329, Tb04.1H19.930 |
| Clonality |
Monoclonal (7-00E-02) |
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Host
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Reactivity
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Application
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| Catalog no. |
ABIN180046 |
| Quantity |
100 µg |
| Price |
517.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 10 to 15 Business Days |
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Alternative name
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OGG1 (8-oxoguanine DNA glycosylase 1)
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Immunogen
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Recombinant Human OGG1
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Isotype
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IgG1 (Matching secondary antibodies)
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Clone
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7-00E-02
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Description
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Oxidative damage to DNA has been proposed to have a role in cancer and ageing. Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA, and 7, 8-dihydro-8-oxoguanine (8-oxoG) is one of the adducts formed. Eukaryotic replicative DNA polymerases replicate DNA containing 8-oxoG by inserting an adenine opposite the lesion, consequently, 8-oxoG is highly mutagenic and causes G:C to T:A transversions. Genetic studies in yeast have indicated a role for mismatch repair in minimizing the incidence of these mutations. In Saccharomyces cerevisiae, deletion of OGG1, encoding a DNA glycosylase that functions in the removal of 8-oxoG when
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Application Notes
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This antibody can be used for western blotting in concentration of 1 ug/ml. Reactivity: confirmed in human OGG1 transfectant Reference:Shinmura K., et al. Expression of the OGG1-type 1a(nuclear form) protein in cancerous and non-cancerous human cells. International Journal of Oncology 2-000 1-6: 7-01-707
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Purification
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Protein A
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Buffer
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Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product
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Storage
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Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20
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Restrictions
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For Research Use only
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Alternatives for antigen "8-Oxoguanine DNA Glycosylase (OGG1)", type "Antibodies"
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Hosts
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Rabbit (14), Goat (4), Mouse (2)
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Reactivities
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Human (13), Mouse (Murine) (5), Rat (Rattus) (5), Primate (2), Primates (1)
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Applications
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Western Blotting (WB) (19), ELISA (3), ELISA (Detection) (3), Enzyme Immunoassay (EIA) (3), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Immunohistochemistry (IHC) (2), Immunofluorescence (IF) (1), Immunoprecipitation (IP) (1)
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Conjugates
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Biotin (1), HRP (1)
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Epitopes
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C-Term (2)
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Alternatives 
