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V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT) antibody
| Antigen | V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT) |
| Synonyms | PBT, SCFR, C-Kit, CD117, W, Bs, Fdc, Ssm, SCO1, SCO5, SOW3, c-KIT, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3, c-kit, kit-A, XKrk1, KIT, MGF, LOC100221238, C-KIT |
| Clonality | Monoclonal (12A8) |
| Host |
 Alternatives Mouse |
| Reactivity |
Alternatives Human |
| Application |
Alternatives Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Neutralization (Neut)
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| Catalog no. | ABIN180067 |
| Quantity | 100 µg |
| Price | 517.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Alternative name | c-kit (12A8) |
| Immunogen | Recombinant protein of extracellular domain of human c-Kit |
| Isotype | IgG1 (Matching secondary antibodies) |
| Clone | 12A8 |
| Description | The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor, and its ligand for c-Kit receptor has been identified as the stem cell factor (SCF). Recent experimental studies have shown that c-Kit plays a key role in the development of a component of the pacemaker system that is required for generation of autonomic gut motility. These studies further suggest that interaction of the c-Kit and SCF is essential for development of enteric nervous system. Recently, it is reported that the c-Kit may be an important marker for gastrointestinal stromal tumors (GISTs) which may originate from the interstitial cells of Cajal (ICCs). This monoclonal antibody recognizes c-Kit by W.B. and I.P. applications and it enables FACS analysis of c-Kit-expressing cells. It has been confirmed that the addition of this antibody does not induce ligand-binding-dependent phosphorylation of c-Kit and it may be used as a neutralizing antibody. |
| Specificity | Confirmed by western blotting with SY cell. |
Application Details
| Application Notes | This antibody can be used for western blotting at 1-5 ug/mL. This antibody can be used for immunoprecipitation at 3-5 ug/mL. |
| Purification | Protein A |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1.0 mL deionized water will be added to the product |
| Storage | Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20 |
| Research Area | Proliferation Markers |
| Restrictions | For Research Use only |
Images
Alternatives
Alternatives for antigen "V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT)", type "Antibodies"
| Hosts | Rabbit (85), Mouse (52), Rat (38) |
| Reactivities | Human (117), Mouse (Murine) (59), Rat (Rattus) (18), Chicken (9), Dog (Canine) (6), Cow (Bovine) (5), Primate (4), Monkey (2), Pig (Porcine) (2) |
| Applications | Flow Cytometry (FACS) (69), Western Blotting (WB) (54), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (43), Enzyme Immunoassay (EIA) (24), Immunohistochemistry (IHC) (21), Immunohistochemistry (Frozen Sections) (IHC (fro)) (18), ELISA (12), Immunoprecipitation (IP) (11), Immunofluorescence (IF) (8), Dot Blot (Dot) (5), Immunocytochemistry (ICC) (4), ELISA (Detection) (1), Functional Studies (Func) (1) |
| Conjugates | PE (14), FITC (12), Biotin (6), APC (2), APC,Cy7 (2), Cy5 (2), SPRD (2), RPE (1) |
| Epitopes | pTyr721 (10), C-Term (4), pTyr936 (4), N-Term (2), pTyr719 (2), Y721 (1), pS741 (1), pY703 (1), pY721 (1), pY936 (1) |
