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Product Details

anti-Bcl-1/cyclin D1 antibody

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Image for anti-Bcl-1/cyclin D1 antibody
Antigen: Bcl-1/cyclin D1
Clonality: Monoclonal (5D4)
Application: Immunohistochemistry (IHC), Western Blotting (WB)
Reactivity: Human
Host: Mouse
Quantity: 200 µg
Price: 499,00 $   (Plus shipping costs $25 and VAT, Invoice in EUR)
Order number: ABIN180070
Availability: Ships within 10 to 15 Business days
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Additional Information  » anti-Bcl-1/cyclin D1 antibody

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Antigen Bcl-1/cyclin D1
Immunogen Recombinant Human PRAD1/cyclin D1 (E. coli)
Reactivity Human
Clonality Monoclonal
Isotype IgG2a »Matching secondary antibodies
Description Bcl-1/Cyclin D1 belongs to the G1 cyclins and plays a key role in cell cycle regulation during the G1/S transition by cooperating with cyclin-dependent kinases (CDKs). Its overexpression may lead to growth advantage for tumor cells by way of cell cycle progression, and actually it has been reported in various human cancers, e.g., esophageal, breast, and bladder carcinomas. Among hematolymphoid malignancies, cyclin D1 overexpression resulting from translocational activation has also been recognized in a subset of B-chronic lymphocytic leukemia (B-CLL), multiple myeloma, splenic marginal zone lymphoma, hairy cell leukemia, and mantle cell lymphoma.
Clone 5D4
Host Mouse
Specificity Cross-react with cyclin D2

Application Details  » anti-Bcl-1/cyclin D1 antibody

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Application Immunohistochemistry (IHC), Western Blotting (WB)
» Click here to view 3 available protocols!
Application Notes This antibody can be stained in formalin fixed paraffin embedded tissues after microwave treatment by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 2-5 ug/ml, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 2-5 ug/ml.
Purification Protein A
Buffer Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product
Storage Lyophilized product, 5 years at 2 ­ 8 : Solution, 2 years at ­20
Research Area Cancer
Restrictions For Research Use only