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Cyclin D1 (CCND1) antibody
| Antigen | Cyclin D1 (CCND1) |
| Synonyms |
BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, ...
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| Clonality | Monoclonal (5D4) |
| Host |
 Alternatives Mouse |
| Reactivity |
Alternatives Human |
| Application |
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|
| Catalog no. | ABIN180070 |
| Quantity | 200 µg |
| Price | 517.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business days |
Additional Information
| Alternative name | Bcl-1/cyclin D1 |
| Immunogen | recombinant Human PRAD1/cyclin D1 (E. coli) |
| Isotype | IgG2a (Matching secondary antibodies) |
| Clone | 5D4 |
| Description | Bcl-1/Cyclin D1 belongs to the G1 cyclins and plays a key role in cell cycle regulation during the G1/S transition by cooperating with cyclin-dependent kinases (CDKs). Its overexpression may lead to growth advantage for tumor cells by way of cell cycle progression, and actually it has been reported in various human cancers, e.g., esophageal, breast, and bladder carcinomas. Among hematolymphoid malignancies, cyclin D1 overexpression resulting from translocational activation has also been recognized in a subset of B-chronic lymphocytic leukemia (B-CLL), multiple myeloma, splenic marginal zone lymphoma, hairy cell leukemia, and mantle cell lymphoma. |
| Specificity | Cross-react with cyclin D2 |
| Synonyms | BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, MGC132138, ccnd1, MGC53090, bcl1, prad1, u21b31, MGC69515, d11s287e, CCND1, ccndbp1, MGC137744, ZHM, CCNDBP1, MGC133757, DKFZp468E2216, DKFZp469C1216, DKFZp469H0317 |
Application Details
| Application Notes | This antibody can be stained in formalin fixed paraffin embedded tissues after microwave treatment by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 2-5 ug/ml, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 2-5 ug/ml. |
| Purification | Protein A |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product |
| Storage | Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20 |
| Research Area | Cancer |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Cyclin D1 (CCND1)", type "Antibodies"
| Hosts | Rabbit (49), Mouse (21) |
| Reactivities | Human (60), Rat (Rattus) (36), Mouse (Murine) (33), Monkey (4), Dog (Canine) (2), Guinea Pig (2), Rabbit (2), Cow (Bovine) (1), Orang-Utan (1), Sheep (Ovine) (1) |
| Applications | Western Blotting (WB) (54), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (28), Immunoprecipitation (IP) (18), Immunohistochemistry (Frozen Sections) (IHC (fro)) (12), Immunohistochemistry (IHC) (12), ELISA (11), Enzyme Immunoassay (EIA) (9), Flow Cytometry (FACS) (6), Immunocytochemistry (ICC) (4), Immunofluorescence (IF) (4), ELISA (Detection) (3), Functional Studies (Func) (1) |
| Epitopes | C-Term (3), Center (2), N-Term (2), Ab-286 (1), S90 (1), pThr286 (1) |
