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HGF-a (H487) antibody
| Antigen | HGF-a (H487) |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Human |
| Application |
Immunohistochemistry (IHC), Western Blotting (WB)
|
| Catalog no. | ABIN180125 |
| Quantity | 100 µg |
| Price | 517.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Immunogen | Synthetic peptide for C-Terminal of Human HGF¿ Purification: Affinity Purified with synthetic peptide |
| Isotype | IgG (Matching secondary antibodies) |
| Description | Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid that is processed to generate the mature growth factor consisting of a disulfide-linked 69 kDa ¿ 34 kDa À chain. |
| Specificity | Crossreactivities with Rat HGF¿ . No crossreactivities with Human HGFÀ . |
Application Details
| Application Notes | This antibody can be stained both in frozen sections and in formalin fixed paraffin embedded tissues after trypsin treatment by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 2 ·`5 ug/ml, however, the dilution rate should be optimized by each laboratories.:This antibody can be used for western blotting in concentration of 2 - 5 ug/ml. |
| Purification | Antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product |
| Storage | Lyophilized product, 5 years at 2 8 C : Solution, 2 years at 20 C |
| Restrictions | For Research Use only |
