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Antibodies
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anti-Suppressor of Cytokine Signaling 3 (SOCS3) antibody
Suppressor of Cytokine Signaling 3 (SOCS3) antibody
| Antigen |
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| Synonyms |
SSI-3, socs3, fj09e12, zgc:56537, wu:fj09e12, MGC64393, MGC75749, xsocs3, MGC81248, SOCS-3, cis3, ssi3, atod4, cish3, ssi-3, socs-3, MGC88877, SOCS3 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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| Catalog no. |
ABIN180156 |
| Quantity |
100 µg (Variants) |
| Price |
517.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 10 to 15 Business Days |
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Alternative name
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CIS3/SOCS-3 (C005)
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Immunogen
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Synthetic peptide for a N-terminal part of Human CIS3/SOCS-3 Purification: Affinity purified with synthetic peptide
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Isotype
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IgG (Matching secondary antibodies)
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Description
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The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and transformation through their association with cytokine receptors. The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. The cytokine-inducible SH2 protein-3 (CIS3/SOCS-3/SSI-3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis. Recently, it is reported that CIS3 regulates the erythropoietin (EPO) receptor (EPOR) signaling in erythroid progenitors and Ba/F3 cells expressing the EPOR (BF-ER). CIS3 binds directly to the EPOR as well as JAK2 and inhibits EPO-dependent proliferation and STAT5 activation.
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Specificity
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Antigen peptide is identical among Human, Mouse and Rat
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Application Notes
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This antibody can be used for western blotting in concentration of 1-5 ug/ml. Cross:Antigen is used in same amino acid sequences with human, mouse and rat. Reactivity Cross reacts with mouse, but not tested cross reactivity with rat. Reference: Yoshimura A. The CIS family: negative regulators of JAK-STAT signaling. Cytokine Growth Factor Rev. 9 (3-4): 1-97-204, 1-998 Sasaki A., Yasukawa H., Shouda T., Kitamura T., Dikic I., and Yoshimura A. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 2-75 (38): 2-9338-47, 2-000
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Purification
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Antigen peptide
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Buffer
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Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1.0 ml distilled water will be added to the product
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Storage
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Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20
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Research Area
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Transcription Factors
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Restrictions
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For Research Use only
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Alternatives for antigen "Suppressor of Cytokine Signaling 3 (SOCS3)", type "Antibodies"
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Hosts
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Mouse (10), Rabbit (7), Goat (3)
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Reactivities
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Human (17), Dog (Canine) (2), Cow (Bovine) (1), Mouse (Murine) (1), Pig (Porcine) (1), Rat (Rattus) (1)
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Applications
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Western Blotting (WB) (11), Enzyme Immunoassay (EIA) (8), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), ELISA (2), Immunohistochemistry (IHC) (2), ELISA (Detection) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1), Immunoprecipitation (IP) (1)
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Epitopes
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C-Term (5), N-Term (1)
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Alternatives 
