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N-Cadherin(760) antibody
| Antigen | N-Cadherin(760) |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Human |
| Application |
Immunohistochemistry (IHC)
|
| Catalog no. | ABIN180177 |
| Quantity | 100 µg |
| Price | 517.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Immunogen | Synthetic peptide of aa 746-761 (KRRDKERQAKQLLI) of human N-Cadherin Purification: Affinity purified with synthetic peptide |
| Isotype | IgG (Matching secondary antibodies) |
| Description | Cadherins are a family of Ca2+-dependent intercellular adhesion molecules. They play an important role in cell-cell interaction, histogenesis and cellular transformation, and association with the actin cytoskeleton regulates their function by a complex of cytoplasmic proteins called the catenins (, , ). Among the cadherin protein family, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of -catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphory- lation events. |
Application Details
| Application Notes | This antibody can be stained in formalin fixed paraffin embedded tissues after microwave treatment. The optimal dilution is 5 ug/ml, however, the dilution rate should be optimized by each laboratories. |
| Purification | Antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product |
| Storage | Lyophilized product, 5 years at 2 8 C : Solution, 2 years at 20 C |
| Restrictions | For Research Use only |
