APP (C-Term) antibody

Antigen: APP

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), Immunoprecipitation (IP)

Catalog no.: ABIN180232

Additional Information

Alternative name: APP (C)

Immunogen: Synthetic peptide in portion of C-terminus of Human APP Purification: Purified with antigen peptide

Isotype: IgG  (Matching secondary antibodies)

Description: Amyloid precursor protein (APP) is precursor protein of Amyloid which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative splicing of common precursor mRNA. Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway. The non-amyloidogenic pathway is mediated by and -secretases and gives rise to a large fragment known as soluble APP (sAPP ) and a small 3 kDa peptide known as p3. On the other hand, the Amyloidogenic pathway is mediated by - and -secretases and yields soluble APP (sAPP) and Amyloid . The physiologic function of APP itself is not clear, however, it is supposed that the function of APP in neuron system is different from that in other organ.

Specificity: Cross-reacts with Mouse and Rat. All isoforms (APP695, APP751, APP770) are detectable. Non-crossreactive to sAPP and sAPP

Application Details

Application Notes: This antibody can be used for western blotting in concentration of about 1 - 2 ug/ml.:This antibody can be used for immunoprecipitation in concentration of about 3g/ml.

Purification: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 Reconstitution: 1.0 ml distilled water will be added to the product, then its concentration comes to 100 ug/ml

Storage: Lyophilized product, 5 years at 2 ­ 8 C : Solution, 2 years at ­20 C

Restrictions: For Research Use only

Images

anti-APP (C-Term) antibody