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RAB27A/B, Member RAS Oncogene Family (Rab27A/B) antibody
| Antigen | RAB27A/B, Member RAS Oncogene Family (Rab27A/B) |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Human |
| Application |
Western Blotting (WB)
|
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1 reference available |
| Catalog no. | ABIN180234 |
| Quantity | 100 µg |
| Price | 517.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Alternative name | Rab27A/B |
| Immunogen | Recombinant Rab27B protein |
| Isotype | IgG (Matching secondary antibodies) |
| Description | Small GTPase Rab is a large family of membrane trafficking proteins that are conserved in all eukaryotic cells. More than 60 Rab isoforms have been reported in mice and humans, and they are believed to regulate various steps (or various types) of organelle transport. The Rab27 subfamily is phylogenetically similar to the Rab3 subfamily, and two Rab27 isoforms, Rab27A and Rab27B, are present in mice and humans. Mutations in the RAB27A gene cause human Griscelli syndrome, which is characterized by pigment dilution and immunodeficiency. The GTP-bound activated form of Rab27A regulates melanosome transport in melanocytes and secretory granule exocytosis (e.g., insulin secretion) through interaction with a specific effector molecule (e.g., Synaptotagmin-like protein (Slp) and Slac2). Rab27B is also expressed on secretory granules, the same as Rab27A, and regulates their exocytosis (e.g., amylase release from rat parotid acinar cells) |
| Specificity | Cross-reacts with mouse and rat Rab27A/B. Does Does not crossreact with the Rab3 subfamily |
Application Details
| Application Notes | This antibody can be used for western blotting in concentration of about 1~5g/mL. |
| Purification | Recombinant human Rab27B |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1.0 ml distilled water will be added to the product, then its concentration comes to 100 ug/ml |
| Storage | Lyophilized product, 5 years at 2 8 C : Solution, 2 years at 20 C |
| Restrictions | For Research Use only |
Publications
| Publications |
Kesari, Fukuda, Knoblach et al.: "Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset." in: The American journal of pathology, Vol. 173, Issue 5, pp. 1476-87, 2008 (PubMed).
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