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Soluble Alpha2,6-Sialyltransferase antibody
| Antigen | Soluble Alpha2,6-Sialyltransferase |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Rat (Rattus) |
| Application |
Western Blotting (WB)
|
| Catalog no. | ABIN180238 |
| Quantity | 100 µg |
| Price | 517.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Immunogen | Synthetic peptide for a part of Rat 2,6-sialyltransferase (E41 Form). Purification: Purified with antigen peptide |
| Isotype | IgG (Matching secondary antibodies) |
| Description | The histopathological picture of Alzheimer's disease is characterized by senile plaques and neurofibrillary tangles, and because the senile plaques form first, they are considered the initial lesion. Senile plaques are known to be formed by accumulation of -amyloid peptide (A). A peptide is produced by the cleavage of amyloid precursor protein (APP) by two types of proteolytic enzymes. The first cleavage is performed by -secretase (BACE1), and the second -secretase. It is thought that their inhibitors may be capable of serving as safe drugs for the treatment of Alzheimer's disease. In recent years a glycosyltransferase involved in the biosynthesis of sugar chains (2,6-sialyltransferase) has also been shown to be cleaved by BACE1. The cleavage site was identified at the same time, and as a result it was demonstrated that in humans it produces cleavage-type 2,6-sialyltransferase (E44 Form) and in rats it produces cleavage-type 2,6-sialyltransferase (E41 Form). This product is purified antibody which can detect Rat 2,6-sialyltransferase (E41 Form). |
| Specificity | Cross-reacts with Rat 2,6-sialyltransferase (E41 Form) No crossreactivities with Human and Mouse 2,6-sialyltransferase |
Application Details
| Application Notes | This antibody can be used for western blotting in concentration of about 1-5ug/mL, however, the dilution rate should be optimized by each laboratories. |
| Purification | Antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 . Reconstitution: 1.0 mLdistilled water will be added to the product, then its concentration comes to 100ug/mL |
| Storage | Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20 |
| Restrictions | For Research Use only |
