Adiponectin Receptor 2 (ADIPOR2) antibody

Antigen: Adiponectin Receptor 2 (ADIPOR2)

Synonyms: PAQR2, ACDCR2, MGC4640, FLJ21432, ADCR2, Paqr2, AI115388, AW554121, D6Ucla1e, 1110001I14Rik, ADIPOR2, MGC134215, MGC84736, zgc:136273, si:ch211-281k12.9, paqr2, acdcr2, LOC100220214

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN180244

Additional Information

Alternative name: Adiponectin Receptor 2

Immunogen: Synthetic peptide of human Adiponectin Receptor 2 Purification: Purified with antigen peptide

Description: It has been reported that mast cells secrete various bioactive substances (adipokines), in addition to serving as a place for energy storage. Adiponectin has been shown to be one of the adiopkines possessing anti-diabetic, anti-atherosclerotic and anti-inflammatory actions. It was recently shown that the blood adiponectin levels were reduced in cases of obesity. As a result, adiponectin has been attracting close attention as a factor playing a central role in the development of the metabolic syndrome. More recently, adiponectin receptors, Adiponectin Receptor 1 (AdipoR1) and Adiponectin Receptor 2 (AdipoR2) have been identified, inviting very close attention. AdipoR2 is expressed particularly prominently in the liver. Unlike the G-protein-coupled receptors (GPCR) reported previously, AdipoR2 can be topologically characterized by an intracellular N-terminal and extracellular C-terminal. Structurally, this receptor seems to belong to a new family of receptors different from the GPCR. AdipoR2 serves as a receptor for globular adiponectin and full-length adiponectin, and has been shown to transmit signals for the stimulation of fat burning, etc., through activation of PPAR and the AMP kinase. Measurement of AdipoR2 is expected to be useful in not only diabetes-related research, but also research on inflammation, atherosclerosis and, as has been shown more recently, tumors.

Specificity: Non cross-react with Adiponectin Receptor 1. Cross-react with Mouse.

Application Details

Application Notes: This antibody can be used for western blotting in concentration of 1-5 ug /mL.

Purification: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 Reconstitution: 1.0mL distilled water will be added to the product (The conc. comes up 100 ug /mL)

Storage: Lyophilized product, 5 years at 2 ­ 8

Restrictions: For Research Use only