Leucine-Rich Repeat Kinase 2 (LRRK2) antibody

Antigen: Leucine-Rich Repeat Kinase 2 (LRRK2)

Synonyms: Gm927, cI-46, AW561911, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, PARK8, RIPK7, ROCO2, AURA17, DARDARIN, LRRK2

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN180251

Additional Information

Alternative name: LRRK2

Immunogen: Synthetic peptide of the C terminal part of Human LRRK2 (HIEVRKELAEKMRRTSVE) Purification: Purified with antigen peptide

Isotype: IgG  (Matching secondary antibodies)

Description: Parkinson's disease is one of the most common neurodegenerative disease and characterized by progressive loss of dopaminergic neurons. Leucine-rich repeat kinase 2 (LRRK2) is one of the responsible gene of autosomal dominant Parkinson's disease. LRRK2 gene codes about 280 kDa protein with 2,527 amino-acid residues and has Leucine-rich repeats, Roc (Ras of complex proteins), COR (C-terminal of Roc), MAPKKK (mitogen-activated protein kinase kinase kinase) and WD40 domains. In recent studies, it has been reported that LRRK2 protein has a kinase activity and the activity increases by a mutation of LRRK2 gene. And the increase of kinase activity has been shown to induce neurologic toxicity. However, there are many unclear points about functions of LRRK2 protein, and its role in pathogenic mechanism of Parkinson's disease is still unknown.

Application Details

Application Notes: This antibody can be used for western blotting in concentration of 1 ­ 3 ug /mL. Reference:1. Hatano T, Kubo S, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N. Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet. 2-007 Mar 1-5,16(6):678-90. 2. Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA. Kinase activity of 1-5,15(2):223-32.

Purification: Antigen peptide

Buffer: Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 Reconstitution: 1.0 mL deionized water will be added to the product (the conc. comes up 100 ug /mL)

Storage: Lyophilized product, 5 years at 2 ­ 8 °C

Restrictions: For Research Use only

Images

anti-Leucine-Rich Repeat Kinase 2 (LRRK2) antibody