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Rat APP (597) antibody
| Antigen | Rat APP (597) |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Mouse (Murine), Rat (Rattus) |
| Catalog no. | ABIN180260 |
| Quantity | 100 µg |
| Price | 517.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Immunogen | Synthetic peptide in portion of C terminus of Mouse/Rat sAPP (DAEFGHDSGFEVRHQK) Purification: Purified with antigen peptide |
| Isotype | IgG (Matching secondary antibodies) |
| Clone | 597 |
| Description | Amyloid precursor protein (APP) is precursor protein of Amyloid which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms. Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway. The non-amyloidogenic pathway is mediated by - and -secretases and gives rise to a large fragment known as soluble APP (sAPP) and a small 3 kDa peptide known as p3. On the other hand, the amyloidogenic pathway is mediated by - and -secretases and yields soluble APP (sAPP) and Amyloid . The physiologic function of APP itself is not clear, however, it is supposed that the function of APP in neuron system is different from that in other organ. |
| Specificity | Does not crossreact with Human Does not crossreact with sAPP |
Application Details
| Application Notes | This antibody can be used for western blotting in concentration of 1 - 5 g/mL.:This antibody can be used for immunoprecipitation in concentration of 3 g/mL. |
| Purification | Antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 . Reconstitution: 1.0 mL deionized water will be added to the product, then its concentration comes to 100 g/mL. |
| Storage | Lyophilized product, 5 years at 2 - 8 °C : Solution, 2 years at 20 °C |
| Restrictions | For Research Use only |
