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Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) antibody

Details for Product No. ABIN180391, Supplier: Log in to see
Antigen
  • ATAR
  • CD270
  • HVEA
  • HVEM
  • LIGHTR
  • TR2
  • Atar
  • HveA
  • Hvem
  • Tnfrs14
Reactivity
Human
137
22
1
Host
Mouse
73
52
14
8
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
14
12
7
6
4
3
2
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF)
102
58
51
30
20
11
9
7
6
2
2
1
1
1
Supplier
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Immunogen Recombinant human TR2 proteinRemarks: Mol. Wt. of Antigen: 32 kDa
Clone 122
Isotype IgG1
Specificity This antibody detects TNF Receptor like 2.
Cellular Localization: Secreted protein.
Characteristics Synonyms: HVEA, Herpesvirus entry mediator A, TR2, Tumor necrosis factor receptor superfamilymember 14, Tumor necrosis factor receptor-like 2
Purification Protein G chromatography
Alternative Name TNFRSF14 / HVEM (TNFRSF14 Antibody Abstract)
Background TNF receptor like-2 (TR2) (also known as herpesvirus entry mediator (HVEM)) is expressed in multiple human tissues and cell lines and shows a constitutive and relatively high expression in peripheral T and B lymphocytes, and monocytes. It is a member of TNF receptor family. TR2/HVEM is a receptor for herpes virus. It also acts as a receptor for LIGHT (also known as HVEM ligand), a member of TNF family. TR2 protein inhibits a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation.Synonyms: HVEA, Herpesvirus entry mediator A, TR2, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2
Gene ID 8764
UniProt Q92956
Pathways
Application Notes Flow Cytometry. Function Blocking (Order Ab without Azide). Immunofluorescence. Recommended positive control: Tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.2 mg/mL
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C for one month or in aliquots at -20 °C for longer.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Zhai, Guo, Hsu et al.: "LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer." in: The Journal of clinical investigation, Vol. 102, Issue 6, pp. 1142-51, 1998 (PubMed).

Mauri, Ebner, Montgomery et al.: "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator." in: Immunity, Vol. 8, Issue 1, pp. 21-30, 1998 (PubMed).

Kwon, Tan, Ni et al.: "A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14272-6, 1997 (PubMed).

Montgomery, Warner, Lum et al.: "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family." in: Cell, Vol. 87, Issue 3, pp. 427-36, 1996 (PubMed).

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