Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) antibody

Details for Product No. ABIN180391
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(114), (21), (17)
(76), (31), (6), (5), (4)
Clonality (Clone)
Monoclonal ()
(8), (6), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)
(71), (52), (41), (19), (15), (14), (10), (10), (6), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN180391
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Immunogen Recombinant human TR2 proteinRemarks: Mol. Wt. of Antigen: 32 kDa
Clone HEA125
Isotype IgG1
Characteristics Synonyms: HVEA, Herpesvirus entry mediator A, TR2, Tumor necrosis factor receptor superfamilymember 14, Tumor necrosis factor receptor-like 2
Purification Protein G chromatography
Alternative Name TNFRSF14 / HVEM
Background TNF receptor like-2 (TR2) (also known as herpesvirus entry mediator (HVEM)) is expressedin multiple human tissues and cell lines and shows a constitutive and relatively highexpression in peripheral T and B lymphocytes, and monocytes. It is a member of TNFreceptor family. TR2/HVEM is a receptor for herpes virus. It also acts as a receptor for LIGHT(also known as HVEM ligand), a member of TNF family. TR2 protein inhibits a mixedlymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligandplay a role in T cell stimulation.
UniProt Q92956
Application Notes Flow Cytometry. Function Blocking (Order Ab without Azide). Immunofluorescence. Recommended positive control: Tonsil. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C for one month or in aliquots at -20 °C for longer. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Montgomery, Warner, Lum et al.: "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family." in: Cell, Vol. 87, Issue 3, pp. 427-36, 1996 (PubMed).

Kwon, Tan, Ni et al.: "A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14272-6, 1997 (PubMed).

Mauri, Ebner, Montgomery et al.: "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator." in: Immunity, Vol. 8, Issue 1, pp. 21-30, 1998 (PubMed).

Zhai, Guo, Hsu et al.: "LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer." in: The Journal of clinical investigation, Vol. 102, Issue 6, pp. 1142-51, 1998 (PubMed).

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