Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-99), (N-Term) antibody

Details for Product No. ABIN180435
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Antigen
Epitope
AA 1-99, N-Term
(22), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(67), (25), (8), (1), (1), (1), (1)
Host
Mouse
(68), (15), (2)
Clonality (Clone)
Monoclonal ()
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(69), (26), (25), (18), (17), (13), (7), (5), (4), (3), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN180435
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Immunogen Full length recombinant Human Survivin Protein. AA Sequence: 1-99Remarks: Mol. Wt. of Antigen: 16. 5 kDa
Clone 8E2
Isotype IgG1
Characteristics Synonyms: Survivin, Apoptosis inhibitor 4, API4, Baculoviral IAP repeat-containing protein 5,Apoptosis inhibitor survivin
Purification Protein G Chromatography
Alternative Name IAP4 / BIRC5
Background Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of thecell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates withmicrotubules of the mitotic spindle in a specific and saturable reaction that is regulated bymicrotubule dynamics. Disruption of survivin-microtubule interactions results in loss ofsurvivin's antiapoptosis function and increased caspase-3 activity, a mechanism involvedin cell death, during mitosis. It indicates that survivin may counteract a default inductionof apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome thisapoptotic checkpoint and favour aberrant progression of transformed cells throughmitosis.
UniProt O15392
Research Area Cancer, Apoptosis/Necrosis, Neurology
Application Notes Immunofluorescence. Immunohistology. Recommended positive control: HeLa Cells. Not suitable for Western Blotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 10mM PBS, pH 7.4 0.09% Sodium Azide 0.2 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody at 4°C. Do not freeze! Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Ambrosini, Adida, Altieri: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, 1997 (PubMed).

Lu, Altieri, Tanigawa: "Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas." in: Cancer research, Vol. 58, Issue 9, pp. 1808-12, 1998 (PubMed).

Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

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