anti-HER2 antibody (V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian)) (C-Term)

Details for Product anti-ERBB2 Antibody No. ABIN180481
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Antigen
Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, Erbb-2, Neu, c-erbB2, c-neu, mKIAA3023
Epitope
C-Term
(114), (82), (67), (60), (57), (48), (46), (44), (33), (32), (29), (24), (23), (19), (16), (16), (16), (16), (16), (15), (15), (15), (15), (15), (15), (15), (15), (14), (14), (14), (14), (13), (12), (12), (12), (12), (10), (8), (8), (8), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(1154), (405), (250), (10), (9), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Host
Rabbit
(914), (351), (23), (19), (5), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
This HER2 antibody is un-conjugated
(72), (60), (53), (46), (45), (41), (10), (10), (9), (9), (9), (9), (9), (9), (2), (2), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(630), (445), (333), (283), (218), (209), (127), (119), (91), (65), (63), (21), (20), (16), (10), (6), (5), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.5 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Immunogen A synthetic cyclic peptide from the antigen's C-terminus.
Clone BV5
Isotype IgG
Specificity Cellular Localization:Membrane.
Characteristics Synonyms: HER-2, NEU, p185erbB2, NGL, c-erbB-2, MNL19, Receptor tyrosine-protein kinase erbB-2,NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2
Purification Supernatant
Alternative Name CD340 / ERBB2 / HER2 (ERBB2 Antibody Abstract)
Background HER2/neu (also known as c-erbB-2) is a member of the epidermal growth factor receptor (EGFR) family notable for its role in the pathogenesis of breast cancer and as a target of treatment. It is a cell membrane surface-bound tyrosine kinase normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is a proto-oncogene located at the long arm of human chromosome 17(17q11.2-q12).Synonyms: HER-2, MNL19, NEU, NEU proto-oncogene, NGL, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2, c-erbB-2, p185erbB2
Gene ID 2064
UniProt P04626
Application Notes Positive Control: Breast carcinoma
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Buffer pH 7.5, containing BSA as stabilizer and Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody (undiluted) at 2-8 °C.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Jacobs, Gown, Yaziji et al.: "HER-2/neu protein expression in breast cancer evaluated by immunohistochemistry. A study of interlaboratory agreement." in: American journal of clinical pathology, Vol. 113, Issue 2, pp. 251-8, 2000 (PubMed).

Gorlick, Huvos, Heller et al.: "Expression of HER2/erbB-2 correlates with survival in osteosarcoma." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 17, Issue 9, pp. 2781-8, 2000 (PubMed).

Keshgegian, Cnaan: "erbB-2 oncoprotein expression in breast carcinoma. Poor prognosis associated with high degree of cytoplasmic positivity using CB-11 antibody." in: American journal of clinical pathology, Vol. 108, Issue 4, pp. 456-63, 1997 (PubMed).

Wright, Angus, Nicholson et al.: "Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer." in: Cancer research, Vol. 49, Issue 8, pp. 2087-90, 1989 (PubMed).

Wright, Nicholson, Angus et al.: "Relationship between c-erbB-2 protein product expression and response to endocrine therapy in advanced breast cancer." in: British journal of cancer, Vol. 65, Issue 1, pp. 118-21, 1992 (PubMed).

Validation Images
Catalog No. ABIN180481
544.50 $
Plus shipping costs $45.00
Quantity
Price
0.5 mL
544.50 $

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