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Details for Product No. ABIN180481

V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (C-Term) antibody

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Antigen
Synonyms Neu, HER2, HER-2, c-neu, Erbb-2, c-erbB2, mKIAA3023, CD340, HER-2/neu, MLN 19, NEU, NGL, TKR1
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 5 references available
Catalog no. ABIN180481
Quantity 0.5 mL
Price
489.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen A synthetic cyclic peptide from the antigen's C-terminus.
Clone BV5
Isotype IgG
Characteristics Synonyms: HER-2, NEU, p185erbB2, NGL, c-erbB-2, MNL19, Receptor tyrosine-protein kinase erbB-2,NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2
Purification Supernatant
Alternative Name CD340 / ERBB2 / HER2
Background HER2/neu (also known as c-erbB-2) is a member of the epidermal growth factor receptor(EGFR) family notable for its role in the pathogenesis of breast cancer and as a target oftreatment. It is a cell membrane surface-bound tyrosine kinase normally involved in thesignal transduction pathways leading to cell growth and differentiation. HER2 is aproto-oncogene located at the long arm of human chromosome 17(17q11. 2-q12).
UniProt P04626
Application Notes Positive Control: Breast carcinomaOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Buffer pH 7.5, containing BSA as stabilizer and Sodium Azide as preservative.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody (undiluted) at 2-8°C. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Wright, Nicholson, Angus et al.: "Relationship between c-erbB-2 protein product expression and response to endocrine therapy in advanced breast cancer." in: British journal of cancer, Vol. 65, Issue 1, pp. 118-21, 1992 (PubMed).

Wright, Angus, Nicholson et al.: "Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer." in: Cancer research, Vol. 49, Issue 8, pp. 2087-90, 1989 (PubMed).

Keshgegian, Cnaan: "erbB-2 oncoprotein expression in breast carcinoma. Poor prognosis associated with high degree of cytoplasmic positivity using CB-11 antibody." in: American journal of clinical pathology, Vol. 108, Issue 4, pp. 456-63, 1997 (PubMed).

Gorlick, Huvos, Heller et al.: "Expression of HER2/erbB-2 correlates with survival in osteosarcoma." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 17, Issue 9, pp. 2781-8, 2000 (PubMed).

Jacobs, Gown, Yaziji et al.: "HER-2/neu protein expression in breast cancer evaluated by immunohistochemistry. A study of interlaboratory agreement." in: American journal of clinical pathology, Vol. 113, Issue 2, pp. 251-8, 2000 (PubMed).

Alternatives for antigen "V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2)", type "Antibodies"
Hosts (495), (185), (19), (13), (5), (1)
Reactivities (676), (286), (225), (93), (60), (48), (37), (24), (9), (2), (1), (1), (1), (1)
Applications (420), (218), (187), (176), (148), (110), (100), (43), (36), (29), (28), (18), (7), (5), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1)
Conjugates (25), (11), (10), (10), (10), (10), (10), (10), (10), (10), (10)
Epitopes (52), (47), (41), (40), (38), (29), (29), (21), (17), (12), (10), (9), (8), (7), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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