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Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) (MAGEA1) antibody

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Dog (Canine), Human, Rat (Rattus)
(131), (7), (6), (2), (1)
(100), (31)
Clonality (Clone)
Monoclonal ()
(6), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(77), (56), (45), (45), (15), (14), (11), (10), (3), (3), (2)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Partially purified, full length recombinant human MAGE-1 protein. Remarks: Mol. Wt. of Antigen: 42-46 kDa
Clone MA454
Isotype IgG1
Characteristics Synonyms: MAGE 1, MAGE1, Melanoma-associated antigen 1, MAGEA1, MAGE1A
Purification Protein G chromatography
Alternative Name MAGE-1 (MAGEA1 Antibody Abstract)
Background Human malignant neoplasms carry rejection antigens that are recognized by the patients'autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). Animportant group of antigens is coded by the MAGE family of genes. It was identified thatmelanomas and primary glial brain tumors express common melanoma associatedantigens (MAAs). Because MAGE-1 is expressed on a significant proportion of humanneoplasms of various histological types (melanoma, brain tumors of glial origin,neuroblastoma, nonsmall cell lung cancer, breast, gastric, colorectal, ovarian, renal cellcarcinomas) and not on normal tissues, the encoded antigen may serve as a marker ofearly detection and target for cancer immunotherapy.
UniProt P43355
Application Notes Immunofluorescence. Western Blotting: 0.5-1.0 ug/ml for 2 hrs at RT. Immunohistology (Formalin/paraffin only): use 4-8 ug/ml for 30 min at RT, staining offormalin-fixed tissues REQUIRES boiling tissue sections in 1 mM EDTA, pH 8.0, for 10-20minfollowed by cooling at RT for 20 min. Positive Control: Colo32 cells Germ cells in testis. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) (MAGEA1) antibody (ABIN180508) anti-Melanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) (MAGEA1) antibody
Background publications Jungbluth, Stockert, Chen et al.: "Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours." in: British journal of cancer, Vol. 83, Issue 4, pp. 493-7, 2000 (PubMed).

Chen, Stockert, Tsang et al.: "Immunophenotyping of melanomas for tyrosinase: implications for vaccine development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 18, pp. 8125-9, 1995 (PubMed).

Catalog No. ABIN180508

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