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Stratifin antibody (SFN)

Details for Product anti-SFN Antibody No. ABIN180589, Supplier: Login to see New
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Synonyms YWHAS, Er, Mme1, Ywhas
(167), (48), (34), (9), (4), (4), (4), (3), (3), (1), (1), (1)
(130), (29), (17), (3), (1)
Clonality (Clone)
Monoclonal ()
This Stratifin antibody is un-conjugated
(8), (8), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(146), (71), (55), (39), (30), (18), (17), (15), (11), (5), (3), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 10 to 12 Business Days
Immunogen Recombinant human 14-3-3 sigma proteinRemarks: Mol. Wt. of Antigen: 26-30 kDa
Clone 1433S01
Isotype IgG1
Specificity This antibody is highly specific to 14.3.3 sigma and shows no cross-reaction with other isoforms of 14.3.3.
Cellular Localization: Cytoplasmic.
Characteristics Synonyms: Stratifin, HME1, Epithelial cell marker protein 1
Purification Protein G Chromatography.
Alternative Name 14-3-3 Protein sigma / SFN (SFN Antibody Abstract)
Background 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14-3-3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. 14-3-3 sigma shares cyclin-Cdk2 binding motifs with different cell cycle regulators, including p107, p130, p21Cip1, p27Kip1, and p57Kip2 and is associated with cyclin-Cdk complexes in vitro and in vivo.Synonyms: Epithelial cell marker protein 1, HME1, Stratifin
Gene ID 2810
UniProt P31947
Pathways p53 Signaling
Application Notes Immunofluorescence. Western Blotting: 1 μg/mL for 2 hrs at RT. Immunoprecipitation: use Protein G, 2 g/mg protein lysate. Immunohistology (Formalin/paraffin): 2-4 μg/mL for 30 min at RT, staining of formalin-fixedtissues REQUIRES boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minfollowed by cooling at RT for 20 min. Positive Control: HT29 cells. Skin.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.2 mg/mL
Buffer 10 mM PBS, pH 7.4 containing 0.2 % BSA as stabilizer and 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: One year from despatch
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Stratifin antibody (SFN) (ABIN180589) anti-Stratifin (SFN) antibody
Background publications Villaret, Wang, Dillon et al.: "Identification of genes overexpressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis." in: The Laryngoscope, Vol. 110, Issue 3 Pt 1, pp. 374-81, 2000 (PubMed).

Hermeking, Lengauer, Polyak et al.: "14-3-3 sigma is a p53-regulated inhibitor of G2/M progression." in: Molecular cell, Vol. 1, Issue 1, pp. 3-11, 1998 (PubMed).

Catalog No. ABIN180589
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