Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody

Details for Product No. ABIN180686
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Antigen
Reactivity
Human
(316), (105), (79), (34), (32), (22), (19), (18), (18), (16), (6), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(218), (139), (9), (5), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(17), (16), (9), (6), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(244), (110), (103), (67), (62), (53), (51), (43), (31), (26), (8), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.5 mL
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN180686
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Immunogen E-cadherin and GST recombinant proteinRemarks: Mol. Wt. of Antigen: 120 kDa
Clone NCH-38
Isotype IgG1
Characteristics Synonyms: Epithelial cadherin, E-cadherin, Uvomorulin, CAM 120/80, CDH1, CDHE, UVO
Purification Supernatant
Alternative Name CD324 / Cadherin-1
Background E-cadherin (uvomorulin, cell- CAM120/80) is a calcium dependent cell adhesion moleculeexpressed predominately in epithelial tissues. It plays an important role in the growth anddevelopment of cells via the mechanisms of control of tissue architecture and themaintenance of tissue integrity. Numerous studies have demonstrated that reductionand/or loss of E-cadherin expression in carcinomas correlates positively with the potentialof these tumors for invasion and metastasis.
UniProt P12830
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Application Notes Immunohistology (Formalin/paraffin only): 1: 5-1: 10 for 30 min at RT, staining offormalin-fixed tissues REQUIRES boiling tissue sections in 10 mM citrate buffer, pH 6.0, for10-20 min followed by cooling at RT for 20 min. Positive Control: Breast carcinoma. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody anti-Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) antibody
Background publications Bànkfalvi, Terpe, Breukelmann et al.: "Immunophenotypic and prognostic analysis of E-cadherin and beta-catenin expression during breast carcinogenesis and tumour progression: a comparative study with CD44." in: Histopathology, Vol. 34, Issue 1, pp. 25-34, 1999 (PubMed).

Ilyas: "Adhesion molecule expression in breast cancer: the phoenix in tumour metastasis?" in: The Journal of pathology, Vol. 190, Issue 1, pp. 3-5, 2000 (PubMed).

Bukholm, Nesland, Børresen-Dale: "Re-expression of E-cadherin, alpha-catenin and beta-catenin, but not of gamma-catenin, in metastatic tissue from breast cancer patients [seecomments]." in: The Journal of pathology, Vol. 190, Issue 1, pp. 15-9, 2000 (PubMed).

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