You are viewing an incomplete version of our website. Please click to reload the website as full version.

KI-67 antibody (Antigen Identified By Monoclonal antibody Ki-67)

Details for Product anti-MKI67 Antibody No. ABIN180896, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

(373), (65), (37), (27), (11), (11), (5), (3)
(177), (144), (44), (12), (3)
Clonality (Clone)
Monoclonal ()
This KI-67 antibody is un-conjugated
(12), (8), (7), (7), (5), (5), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF)
(131), (118), (116), (86), (65), (39), (39), (35), (18), (10), (10), (6), (6), (3), (3), (3), (2), (1), (1), (1)
Pubmed 7 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 2 mL
Shipping to United States ( )
Immunogen Human tumour cell line. Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63-Ag8. 653 myeloma cell line.
Clone Ki67
Isotype IgG1
Specificity This antibody reacts with a nuclear antigen that is expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (Go) cells. The monoclonal antibody is useful in establishing the cell growing fraction in neoplasms (Immunohistochemically quantified by determining the number of Ki67-positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidinelabelling index. The correlation between low Ki67 index and histologically low-grade tumours is strong.
Characteristics Synonyms: Ki67 antigen, MKI67, Proliferation marker
Purification Supernatant
Alternative Name Ki-67 (MKI67 Antibody Abstract)
Background Ki-67 is a nuclear protein that is expressed in proliferating cells and may be required for maintaining cell proliferation. Ki-67 has been used as a marker for cell proliferation of solid tumors and some hematological malignancies. A correlation has been demonstrated between Ki-67 index and the histopathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors.Synonyms: Ki67 antigen, MKI67, Proliferation marker
Gene ID 4288
UniProt P46013
Research Area Proliferation Markers, Cell Cycle
Application Notes Immunofluorescence. Flow Cytometry: Use 10 μL of Neat-1/5 diluted antibody to label 10^6 cells in 100 μL (Cellpermeabilisation is required). Immunohistochemistry on Frozen Sections: 1/10-1/50. Recommended Positive Control: Tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Immunofluorescence (IF) image for anti-KI-67 antibody (Antigen Identified By Monoclonal antibody Ki-67) (ABIN180896) anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) antibody
Background publications Gerdes, Schwab, Lemke et al.: "Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation." in: International journal of cancer. Journal international du cancer, Vol. 31, Issue 1, pp. 13-20, 1983 (PubMed).

Gerdes, Lemke, Baisch et al.: "Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 133, Issue 4, pp. 1710-5, 1984 (PubMed).

Grogan, Lippman, Spier et al.: "Independent prognostic significance of a nuclear proliferation antigen in diffuse large cell lymphomas as determined by the monoclonal antibody Ki-67." in: Blood, Vol. 71, Issue 4, pp. 1157-60, 1988 (PubMed).

Hall, Richards, Gregory et al.: "The prognostic value of Ki67 immunostaining in non-Hodgkin's lymphoma." in: The Journal of pathology, Vol. 154, Issue 3, pp. 223-35, 1988 (PubMed).

Grogan, Miller: "New biologic markers in non-Hodgkin's lymphomas." in: Hematology/oncology clinics of North America, Vol. 5, Issue 5, pp. 925-33, 1991 (PubMed).

Freedman, Nadler: "Immunologic markers in non-Hodgkin's lymphoma." in: Hematology/oncology clinics of North America, Vol. 5, Issue 5, pp. 871-89, 1991 (PubMed).

Houmand, Abrahamsen, Tinggaard Pedersen: "Relevance of Ki-67 expression in the classification of non-Hodgkin's lymphomas: a morphometric and double-immunostaining study." in: Histopathology, Vol. 20, Issue 1, pp. 13-20, 1992 (PubMed).

Catalog No. ABIN180896

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)