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C3 antibody

C3 Reactivity: Human WB, IHC (fro), EIA, FACS Host: Mouse Monoclonal 10-02A unconjugated
Catalog No. ABIN181106
  • Target See all C3 Antibodies
    C3 (Complement Component 3 (C3))
    Reactivity
    • 94
    • 57
    • 35
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    Human
    Host
    • 72
    • 47
    • 28
    • 8
    • 7
    • 6
    Mouse
    Clonality
    • 129
    • 38
    Monoclonal
    Conjugate
    • 75
    • 24
    • 24
    • 15
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    This C3 antibody is un-conjugated
    Application
    • 110
    • 54
    • 40
    • 35
    • 34
    • 30
    • 30
    • 29
    • 23
    • 18
    • 14
    • 13
    • 13
    • 9
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Flow Cytometry (FACS)
    Specificity
    This antibody recognises 135 kDa complement component 3c (C3c), present in blood serum.
    Characteristics
    Synonyms: CPAMD1, Complement component 3, C3 and PZP-like alpha-2-macroglobulindomain-containing protein 1
    Purification
    Affinity chromatography on Protein A
    Immunogen
    Native human C3 from normal serum, highly purified by chromatography. Genename: C3c
    Clone
    10-02A
    Isotype
    IgG1
    Top Product
    Discover our top product C3 Primary Antibody
  • Application Notes
    ELISA: This antibody binds both C3c and C3 and so is not suitable for all ELISAapplications. Western Blot. Flow Cytometry. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptococal glomerulonephritispatients.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0mg/mL
    Buffer
    Borate buffered saline pH 8.4 containing 0.02 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    C3 (Complement Component 3 (C3))
    Alternative Name
    Complement C3 (C3 Products)
    Synonyms
    AHUS5 antibody, ARMD9 antibody, ASP antibody, C3a antibody, C3b antibody, CPAMD1 antibody, AI255234 antibody, HSE-MSF antibody, Plp antibody, C3 antibody, C3-1 antibody, sb:cb26 antibody, si:dkey-76b14.4 antibody, wu:fi34b03 antibody, wu:fj86e11 antibody, C3d antibody, asp antibody, cpamd1 antibody, c3 antibody, complement C3 antibody, complement component 3 antibody, complement component c3a, duplicate 1 antibody, complement component 3 L homeolog antibody, complement component C3 antibody, complement C3-like antibody, C3 antibody, c3a.1 antibody, c3.L antibody, LOC443475 antibody, c3 antibody, c3-1 antibody, LOC100060539 antibody
    Background
    C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha chain fragment 1 + alpha chain fragment 2), C3dg and C3f. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CPAMD1, Complement component 3
    Gene ID
    718
    UniProt
    P01024
    Pathways
    Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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