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Complement Factor B antibody (Fragment Bb)

CFB Reactivity: Human WB, FACS, EIA, IHC (fro) Host: Mouse Monoclonal 10-09-14 unconjugated
Catalog No. ABIN181113
  • Target See all Complement Factor B (CFB) Antibodies
    Complement Factor B (CFB)
    Binding Specificity
    • 15
    • 10
    • 9
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Fragment Bb
    Reactivity
    • 70
    • 44
    • 35
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 91
    • 14
    • 2
    Mouse
    Clonality
    • 92
    • 14
    • 1
    Monoclonal
    Conjugate
    • 45
    • 19
    • 15
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Complement Factor B antibody is un-conjugated
    Application
    • 80
    • 39
    • 30
    • 15
    • 13
    • 13
    • 12
    • 10
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody recognises the Bb fragment of 90 kDa complement factor B, present in blood serum.
    Characteristics
    Synonyms: Properdin factor B, C3/C5 convertase, PBF2, CFB, BF, BFD, Glycine-rich beta glycoprotein
    Purification
    Affinity chromatography on Protein A
    Immunogen
    Human factor B
    Clone
    10-09-14
    Isotype
    IgG1
    Top Product
    Discover our top product CFB Primary Antibody
  • Application Notes
    ELISA: This antibody binds to both the Bb fragment and complement factor B so is notsuitable for all ELISA applications. Western Blot. Flow Cytometry. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptocial glomerlulonephritis patients.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0mg/mL
    Buffer
    Borate buffered saline containing 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Target
    Complement Factor B (CFB)
    Alternative Name
    Complement Factor B (CFB Products)
    Synonyms
    AHUS4 antibody, BF antibody, BFD antibody, CFAB antibody, FB antibody, FBI12 antibody, GBG antibody, H2-Bf antibody, PBF2 antibody, bf antibody, Bf-1 antibody, Brre-Bf antibody, zgc:114032 antibody, Bf antibody, Sp152 antibody, bfb-A antibody, Bf B antibody, LOC397725 antibody, bf/c2 antibody, CFB antibody, AI195813 antibody, AI255840 antibody, B antibody, C2 antibody, Fb antibody, Da1-24 antibody, complement factor B antibody, complement factor B S homeolog antibody, complement factor B L homeolog antibody, CFB antibody, cfb antibody, bf antibody, cfb.S antibody, cfb.L antibody, bf/c2 antibody, LOC100555981 antibody, Cfb antibody
    Background
    C3b associates with complement factor B, inducing conformational change which enables complement factor D to cleave the N-terminal of complement factor B, the Ba subunit, leaving the 63 kDa Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation.Synonyms: BF, BFD, C3/C5 convertase, CFB, Glycine-rich beta glycoprotein, PBF2, Properdin factor B
    Gene ID
    629
    UniProt
    P00751
    Pathways
    Complement System, Proton Transport, Ribonucleoside Biosynthetic Process
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