CCL19 antibody

Catalog No. ABIN181150

Product Details anti-CCL19 Antibody

Target: CCL19 (Chemokine (C-C Motif) Ligand 19 (CCL19))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCL19 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Specificity: This antibody detects MIP-3 beta.

Characteristics: Synonyms: C-C motif chemokine 19, CCL-19, ELC, MIP3B, MIP-3 beta, Small-inducible cytokine A19,SCYA19, Exodus-3, Small-inducible cytokine A19, EBI1-ligand chemokine, Beta chemokineexodus-3, CK beta-11, Macrophage inflammatory protein 3 beta

Purification: Protein A chromatography

Immunogen: Recombinant human MIP-3-beta

Isotype: IgG1

Application Details

Application Notes: ELISA: In a sandwich ELISA (assuming 100 l/well), a concentration of 2-3 μg/mL of thisantibody will detect at least 0.2 ng/well of recombinant human MIP-3-beta when used withbiotinylated antigen affinity purified anti-human MIP-3-beta as the detection antibody at aconcentration of at least 0.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in sterile water to a concentration of 1 mg/mL.

Preservative: Azide free

Storage: 4 °C/-20 °C

Storage Comment: The lyophilized antibody is stable at room temperature for one month or at -20 °C forlonger. Following reconstitution it is stable at 2 - 8 °C for six weeks. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CCL19

Target: CCL19 (Chemokine (C-C Motif) Ligand 19 (CCL19))

Alternative Name: MIP3-beta / CCL19 (CCL19 Products)

Synonyms: CKb11 antibody, ELC antibody, MIP-3b antibody, MIP3B antibody, SCYA19 antibody, CCL19 antibody, Scya19 antibody, exodus-3 antibody, C-C motif chemokine ligand 19 antibody, chemokine (C-C motif) ligand 19 antibody, CCL19 antibody, ccl19 antibody, Ccl19 antibody

Background: MIP3 chemokines are among many novel beta chemokines recently identified through bioinformatics in the Expressed Sequence Tag (EST) database. They are distantly related to other beta chemokines (20-30 % aa sequence homology). MIP3 chemokines are useful probes for studying the biology of inflammation and cell migration. Their expression is strongly up-regulated by inflammatory signals and down-regulated by the anti-inflammatory cytokine IL10. MIP3 beta is also known as ELC (EBI1-1 ligand chemokine) and is constitutively expressed in various lymphoid tissues (thymus, lymph nodes, appendix and spleen). MIP3 beta is a chemoattractant for cultured human lymphocytes, dendritic cells, human T lymphoblastoid CEM NKR2 and hemopoietic progenitor cells. It may be involved in G Protein activation in human NK cells. MIP3 beta is a unique functional ligand for CCR7. The MIP3 beta gene has been mapped to chormosome 9p13.Synonyms: Beta chemokine exodus-3, C-C motif chemokine 19, CCL-19, CK beta-11, EBI1-ligand chemokine, ELC, Exodus-3, MIP-3 beta, MIP3B, Macrophage inflammatory protein 3 beta, SCYA19, Small-inducible cytokine A19, Small-inducible cytokine A19

Gene ID: 6363

UniProt: Q99731

Pathways: Positive Regulation of Immune Effector Process