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Details for Product No. ABIN181311

Cyclin D1 (CCND1) (C-Term) antibody

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Antigen
Synonyms
BCL1, PRAD1, U21B31, D11S287E, AI327039, CycD1, Cyl-1, bcl-1, cD1, cb161, cycd1, etID37810.7, fb52e01, fc45c08, fc83a12, id:ibd1198, wu:fb52e01, wu:fc45c08, wu:fc83a12, ccnd1, ccnd1a, prad1, ccnd1b, b ... show more
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN181311
Quantity 0.5 mg
Price
599.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen A synthetic peptide derived from the C-terminal of human Cyclin D.
Specificity Higly specific for Cyclin D1.
Purification Protein A affinity purified immunoglobulin fraction
Alternative Name Cyclin D1
Background Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. It is a putative proto- oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL).
Alternate names: BCL-1 oncogene, BCL1, CCND1, Cyclin-D1, G1/S-specific cyclin-D1, PRAD-1 oncogene, PRAD1
Cellular Localization: Nuclear.
Molecular Weight 36kD.
Gene ID 595
NCBI Accession NP_444284.1
UniProt P24385
Research Area Cancer, Cell Cycle
Application Notes Immunofluorescence. Immunoprecipitation: use Protein A and Ab at 10 g/mg proteinlysate. Western Blotting: Ab 5 ug/ml 2HR. RT. Recommended positive control: MAD109cells, Breast Carcinoma or Mantle Cell Lymphoma. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 10mM PBS pH 7.4 with 0.09% sodium azide as preservative and 0.2% BSA as stabilizer.
Preservative Sodium azide
Handling Advice Avoid Repeated freeze/thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Store at 2-8°C for up to one month or in aliquots at -20°C for longer.
Expiry Date 12 months
Background publications Lukas, Bartkova, Rohde et al.: "Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity." in: Molecular and cellular biology, Vol. 15, Issue 5, pp. 2600-11, 1995 (PubMed).

Lukas, Bartkova, Welcker et al.: "Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types." in: Oncogene, Vol. 10, Issue 11, pp. 2125-34, 1995 (PubMed).

Lukas, Pagano, Staskova et al.: "Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines." in: Oncogene, Vol. 9, Issue 3, pp. 707-18, 1994 (PubMed).

Alternatives for antigen "Cyclin D1 (CCND1)", type "Antibodies"
Hosts (212), (81), (2)
Reactivities (256), (100), (96), (31), (16), (8), (7), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Applications (229), (96), (80), (72), (42), (41), (32), (24), (24), (20), (12), (9), (7), (3), (3), (2), (1), (1), (1)
Conjugates (13), (10), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (32), (18), (12), (7), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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