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VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (C-Term)

Details for Product anti-KDR Antibody No. ABIN181334, Supplier: Log in to see
Antigen
  • vegfr-2
  • KDR
  • 6130401C07
  • Flk-1
  • Flk1
  • Krd-1
  • Ly73
  • VEGFR-2
  • VEGFR2
  • sVEGFR-2
  • Vegfr-2
  • CD309
  • FLK1
  • VEGFR
  • FLK-1
  • flk-1
  • FLK/KDR
  • flk1
  • flk1b
  • kdrb
  • si:busm1-205d10.1
  • si:ch211-254j6.1
  • si:ch211-278f21.4
  • wu:fc31a09
  • fk52c05
  • flk
  • kdr
  • kdra
  • vegfr2
  • vegfr4
  • vegr2
  • wu:fk52c05
  • vascular endothelial growth factor receptor 2
  • kinase insert domain protein receptor
  • kinase insert domain receptor
  • kinase insert domain receptor (a type III receptor tyrosine kinase)
  • kinase insert domain receptor like
  • vascular endothelial growth factor receptor-2
  • vegfr-2
  • Kdr
  • KDR
  • kdr
  • kdrl
Alternatives
anti-Human VEGFR2 antibody for Immunohistochemistry (Frozen Sections)
Epitope
C-Term
86
53
51
39
24
24
24
18
18
18
18
17
14
14
14
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10
8
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6
6
6
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4
4
4
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3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
580
304
154
18
5
4
3
3
2
2
2
1
1
1
1
1
1
1
1
Host
Rabbit
510
127
51
4
2
2
1
Clonality
Polyclonal
Conjugate
This VEGFR2 antibody is un-conjugated
42
27
22
16
15
12
9
7
6
5
4
4
3
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
434
241
214
156
117
85
46
30
26
22
18
16
9
8
7
6
5
3
2
2
1
1
1
1
1
1
Options
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Immunogen A synthetic peptide from C-terminus of the precursor form of the Mouse Flk-1
Specificity This antibody detects CD309/VEGFR-2/Flk-1.
Cellular Localization: Cytoplasmic.
Purification Protein A Chromatography
Alternative Name CD309 / VEGFR-2 / Flk-1 (KDR Antibody Abstract)
Background Flk-1/KDR/Vascular Endothelial Growth Factor Receptor 2, a cell membrane receptor kinase, is a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis. It contains seven immunoglobulin like sequences in the extracellular domain and exhibits sequence similarity to Flt-1 and Flt-4.Synonyms: FLK1, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2
Gene ID 3791
NCBI Accession NP_002244
UniProt P35968
Research Area Cytokines, Receptors
Pathways RTK Signaling
Application Notes Western Blotting: 5-10 μg/mL for 2h at RT. Immunohistochemistry (Formalin/Paraffin): Use VEGFR2 antibody at 1/50 for 60 min at RT. Staining of formalin-fixed tissues Requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. Positive Control: Hey Cells, Angiosarcoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer 10 mM PBS, pH 7.4, 0.09 % Sodium Azide, 0.2 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (C-Term) (ABIN181334) anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (C-Term) antibody
 image for anti-VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase)) (C-Term) (ABIN181334) anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (C-Term) antibody (Image 2)
Background publications Ankoma-Sey, Matli, Chang, Lalazar, Donner, Wong, Warren, Friedman: "Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing." in: Oncogene, Vol. 17, Issue 1, pp. 115-21, 1998 (PubMed).

Ergün, Kiliç, Fiedler, Mukhopadhyay: "Vascular endothelial growth factor and its receptors in normal human testicular tissue." in: Molecular and cellular endocrinology, Vol. 131, Issue 1, pp. 9-20, 1997 (PubMed).

Quinn, Peters, De Vries, Ferrara, Williams: "Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 16, pp. 7533-7, 1993 (PubMed).

Millauer, Wizigmann-Voos, Schnürch, Martinez, Møller, Risau, Ullrich: "High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis." in: Cell, Vol. 72, Issue 6, pp. 835-46, 1993 (PubMed).