TNFRSF1A-Associated Via Death Domain (TRADD) (C-Term) antibody

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Pubmed 2 references available
Quantity 0.5 mg
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Catalog No. ABIN181335
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Immunogen A synthetic peptide from C-terminus of human TRADD.
Specificity This antibody detects TRADD.
Purification Protein A chromatography
Alternative Name TRADD
Background TRADD (TNF-R1-associated Death Domain) is an important mediator of FAS and TNFr1 associated apoptotic signaling. It contains a death domain homologous region (DDH) through which it binds to both FAS and TNF-R1. Overexpression of TRADD causes NFkB activation and apoptosis in absence of TNF.
Alternate names: TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, Tumor necrosis factor receptor type 1-associated DEATH domain protein
Cellular Localization: Cytoplasmic.
Gene ID 8717
NCBI Accession NP_003780
UniProt Q15628
Research Area Cardiovascular, Atherosclerosis, Apoptosis/Necrosis
Application Notes Western Blotting: Ab 5-10 ug/ml for 2 hrs at RT. Immunohistology (formalin/paraffin): Use Ab at 10-20 ug/ml for 30 min at RT. Staining offormalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for10-20 min followed by cooling at RT for 20 min. Recommended positive control: HeLa cells. Tonsil andPlacenta. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA & 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer.
Expiry Date 12 months
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anti-TNFRSF1A-Associated Via Death Domain (TRADD) (C-Term) antibody anti-TNFRSF1A-Associated Via Death Domain (TRADD) (C-Term) antibody
Background publications Baker, Reddy: "Transducers of life and death: TNF receptor superfamily and associated proteins." in: Oncogene, Vol. 12, Issue 1, pp. 1-9, 1996 (PubMed).

Hsu, Xiong, Goeddel: "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation." in: Cell, Vol. 81, Issue 4, pp. 495-504, 1995 (PubMed).

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