TNFRSF1A-Associated Via Death Domain (TRADD) (C-Term) antibody

Details for Product No. ABIN181335
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Antigen
Epitope
C-Term
(17), (8), (8), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(78), (35), (22), (7), (2), (1)
Host
Rabbit
(82), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(68), (32), (29), (27), (12), (12), (11), (10), (7), (6), (1)
Pubmed 2 references available
Quantity 0.5 mg
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Availability Discontinued
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Catalog No. ABIN181335
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Immunogen A synthetic peptide from C-terminus of human TRADD.
Specificity This antibody detects TRADD.
Purification Protein A chromatography
Alternative Name TRADD
Background TRADD (TNF-R1-associated Death Domain) is an important mediator of FAS and TNFr1 associated apoptotic signaling. It contains a death domain homologous region (DDH) through which it binds to both FAS and TNF-R1. Overexpression of TRADD causes NFkB activation and apoptosis in absence of TNF.
Alternate names: TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, Tumor necrosis factor receptor type 1-associated DEATH domain protein
Cellular Localization: Cytoplasmic.
Gene ID 8717
NCBI Accession NP_003780
UniProt Q15628
Research Area Cardiovascular, Atherosclerosis, Apoptosis/Necrosis
Application Notes Western Blotting: Ab 5-10 ug/ml for 2 hrs at RT. Immunohistology (formalin/paraffin): Use Ab at 10-20 ug/ml for 30 min at RT. Staining offormalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for10-20 min followed by cooling at RT for 20 min. Recommended positive control: HeLa cells. Tonsil andPlacenta. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA & 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer.
Expiry Date 12 months
Supplier Images
anti-TNFRSF1A-Associated Via Death Domain (TRADD) (C-Term) antibody anti-TNFRSF1A-Associated Via Death Domain (TRADD) (C-Term) antibody
Background publications Hsu, Xiong, Goeddel: "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation." in: Cell, Vol. 81, Issue 4, pp. 495-504, 1995 (PubMed).

Baker, Reddy: "Transducers of life and death: TNF receptor superfamily and associated proteins." in: Oncogene, Vol. 12, Issue 1, pp. 1-9, 1996 (PubMed).

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