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Matrix Metallopeptidase 15 (Membrane-inserted) (MMP15) (Catalytic Domain) antibody

Details for Product No. ABIN181341
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Antigen
Epitope
Catalytic Domain
(14), (7), (7), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(84), (41), (19), (17), (17), (17)
Host
Rabbit
(87), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(65), (35), (27), (22), (17), (14), (11), (4), (1), (1)
Pubmed 3 references available
Quantity 0.5 mg
Shipping to United States (Change)
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Catalog No. ABIN181341
595.32 $
Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen A synthetic peptide from the catalytic domain of mouse MMP-15 / MT2-MMP protein.
Specificity This antibody detects MMP-15.
Purification Protein A chromatography
Alternative Name MMP-15
Background MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3- MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastsis.
Alternate names: MMP15, MT-MMP 2, MT2-MMP, MT2MMP, MTMMP2, Matrix metalloproteinase-15, Membrane-type matrix metalloproteinase 2, Membrane-type-2 matrix metalloproteinase, SMCP-2
Cellular Localization: Cell membrane and cytoplasmic
Gene ID 4324
NCBI Accession NP_002419.1
UniProt P51511
Research Area Cancer, Extracellular Matrix, Inflammation
Application Notes Immunohistology (Formalin/Paraffin, Use at 1: 25 to 1: 50 for 30 min at RT, No specialpretreatment is required, Recommended Positive Control: Placenta). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA & 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer.
Expiry Date 12 months
Background publications Takino, Sato, Shinagawa et al.: "Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family." in: The Journal of biological chemistry, Vol. 270, Issue 39, pp. 23013-20, 1995 (PubMed).

Sato, Takino, Okada et al.: "A matrix metalloproteinase expressed on the surface of invasive tumour cells." in: Nature, Vol. 370, Issue 6484, pp. 61-5, 1994 (PubMed).

Ueno, Nakamura, Inoue et al.: "Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas." in: Cancer research, Vol. 57, Issue 10, pp. 2055-60, 1997 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN181341
595.32 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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