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Details for Product No. ABIN181341

Matrix Metallopeptidase 15 (Membrane-inserted) (MMP15) (Catalytic Domain) antibody

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Antigen
Synonyms MT2-MMP, AI503551, MTMMP2, SMCP-2
Epitope
»Alternatives Catalytic Domain
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Catalog no. ABIN181341
Quantity 0.5 mg
Price
610.50 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the catalytic domain of mouse MMP-15 / MT2-MMP protein.
Specificity This antibody detects MMP-15.
Purification Protein A chromatography
Alternative Name MMP-15
Background MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3- MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastsis.
Alternate names: MMP15, MT-MMP 2, MT2-MMP, MT2MMP, MTMMP2, Matrix metalloproteinase-15, Membrane-type matrix metalloproteinase 2, Membrane-type-2 matrix metalloproteinase, SMCP-2
Cellular Localization: Cell membrane and cytoplasmic
Gene ID 4324
NCBI Accession NP_002419.1
UniProt P51511
Research Area Cancer, Extracellular Matrix, Inflammation
Application Notes Immunohistology (Formalin/Paraffin, Use at 1: 25 to 1: 50 for 30 min at RT, No specialpretreatment is required, Recommended Positive Control: Placenta). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA & 0.09 % sodium azide.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer.
Expiry Date 12 months
Background publications Takino, Sato, Shinagawa et al.: "Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family." in: The Journal of biological chemistry, Vol. 270, Issue 39, pp. 23013-20, 1995 (PubMed).

Sato, Takino, Okada et al.: "A matrix metalloproteinase expressed on the surface of invasive tumour cells." in: Nature, Vol. 370, Issue 6484, pp. 61-5, 1994 (PubMed).

Ueno, Nakamura, Inoue et al.: "Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas." in: Cancer research, Vol. 57, Issue 10, pp. 2055-60, 1997 (PubMed).

Alternatives for antigen "Matrix Metallopeptidase 15 (Membrane-inserted) (MMP15)", type "Antibodies"
Hosts (71), (5)
Reactivities (72), (38), (17), (17), (17), (17)
Applications (49), (28), (18), (17), (10), (8), (7), (5), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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