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s100b antibody (S100 Calcium Binding Protein B)

Details for Product anti-S100B Antibody No. ABIN181380, Supplier: Log in to see
Antigen
  • AI266795
  • AI850290
  • Bpb
  • NEF
  • S100
  • S100-B
  • S100a
  • S100beta
  • S100P
Reactivity
Chicken, Cow (Bovine), Human, Kangaroo, Mouse (Murine), Rat (Rattus)
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68
60
32
15
4
4
1
Host
Rabbit
178
123
8
3
2
Clonality
Polyclonal
Conjugate
This s100b antibody is un-conjugated
29
27
16
6
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
198
127
117
87
63
61
41
18
12
11
6
4
4
4
4
2
2
1
1
Supplier
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Immunogen S100 protein purified from cow brain.
Specificity This antibody is reactive with S100A and S100B.
Cellular Localization: Cytoplasmic.
Cross-Reactivity (Details) Also reacts to: S100A
Purification Purified IgG
Alternative Name S100B (S100B Antibody Abstract)
Background S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. Antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes.Synonyms: Astrocyte Marker, Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 beta, S100 calcium-binding protein B
Gene ID 525716
NCBI Accession NP_001029727
UniProt P02638
Application Notes ImmunocytochemistryImmunohistology (Formalin/paraffin: use Ab at 1: 100-1: 200 for 30 min at RT, no specialpretreatment is required for histochemical staining of formalin/paraffin tissues). Positive Control: Melanoma or Schwannoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use S100 protein is highly soluble and may be eluted from frozen tissue during staining.
Handling Advice Avoid Repeated freeze/thaw cycles.
Storage 4 °C
Storage Comment Store at 2-8 °C for up to one month or in aliquots at -20 °C for longer.
Supplier Images
 image for anti-s100b antibody (S100 Calcium Binding Protein B) (ABIN181380) anti-S100 Calcium Binding Protein B (S100B) antibody
Background publications Joshi, Lee, Pedersen, Schnitt, Camus, Hughes: "The role of immunocytochemical markers in the differential diagnosis of proliferative and neoplastic lesions of the breast." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 9, Issue 1, pp. 57-62, 1996

McLaren, Cossar: "The immunohistochemical localization of S100 in the diagnosis of papillary carcinoma of the thyroid." in: Human pathology, Vol. 27, Issue 7, pp. 633-6, 1996