S100 Calcium Binding Protein B (S100B) antibody

Details for Product No. ABIN181380
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Cow (Bovine), Chicken, Human, Kangaroo, Mouse (Murine), Rat (Rattus)
(161), (51), (39), (33), (9), (4), (4), (1)
(119), (79), (4), (4), (2)
(12), (11), (8), (6), (6), (6), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(156), (96), (81), (47), (22), (17), (17), (15), (14), (12), (10), (10), (8), (7), (4), (3), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 0.5 mL
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Catalog No. ABIN181380
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Immunogen S100 protein purified from cow brain.
Specificity This antibody is reactive with S100A and S100B.
Cellular Localization: Cytoplasmic.
Cross-Reactivity (Details) Also reacts to: S100A
Purification Purified IgG
Alternative Name S100B
Background S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. Antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes.Synonyms: Astrocyte Marker, Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 beta, S100 calcium-binding protein B
Gene ID 525716
NCBI Accession NP_001029727
UniProt P02638
Application Notes ImmunocytochemistryImmunohistology (Formalin/paraffin: use Ab at 1: 100-1: 200 for 30 min at RT, no specialpretreatment is required for histochemical staining of formalin/paraffin tissues). Positive Control: Melanoma or Schwannoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use S100 protein is highly soluble and may be eluted from frozen tissue during staining.
Handling Advice Avoid Repeated freeze/thaw cycles.
Storage 4 °C
Storage Comment Store at 2-8 °C for up to one month or in aliquots at -20 °C for longer.
Supplier Images
anti-S100 Calcium Binding Protein B (S100B) antibody anti-S100 Calcium Binding Protein B (S100B) antibody
Background publications Joshi, Lee, Pedersen et al.: "The role of immunocytochemical markers in the differential diagnosis of proliferative and neoplastic lesions of the breast." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 9, Issue 1, pp. 57-62, 1996 (PubMed).

McLaren, Cossar: "The immunohistochemical localization of S100 in the diagnosis of papillary carcinoma of the thyroid." in: Human pathology, Vol. 27, Issue 7, pp. 633-6, 1996 (PubMed).

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