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Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody

Details for Product No. ABIN181412
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Antigen
Epitope
C-Term
(22), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(66), (25), (8), (1), (1), (1), (1)
Host
Rabbit
(68), (14), (2)
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(68), (25), (24), (17), (17), (12), (7), (4), (4), (3), (1), (1), (1)
Pubmed 3 references available
Quantity 0.5 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN181412
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Immunogen A synthetic peptide derived from the C-terminus of survivin
Specificity This antibody detects Survivin.
Purification Protein A chromatography
Alternative Name IAP4 / BIRC5
Background Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin’s antiapoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.
Alternate names: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin
Gene ID 332
NCBI Accession NP_001012270.1
UniProt O15392
Research Area Cancer, Apoptosis/Necrosis, Neurology
Application Notes Immunohistology (formalin/paraffin): at 1: 500 for 30 min at RT, staining of formalin-fixedtissues REQUIRES boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minfollowed by cooling at RT for 20 min. Positive Control: Stomach. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA & 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer.
Expiry Date 12 months
Supplier Images
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody
Background publications Ambrosini, Adida, Altieri: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, 1997 (PubMed).

Lu, Altieri, Tanigawa: "Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas." in: Cancer research, Vol. 58, Issue 9, pp. 1808-12, 1998 (PubMed).

Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

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