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Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody

Details for Product No. ABIN181412, Supplier: Login to see
Antigen
  • API4
  • EPR-1
  • AAC-11
  • Api4
  • TIAP
  • survivin40
  • AP14
Alternatives
anti-Human Baculoviral IAP Repeat-Containing 5 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term
20
5
5
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
71
36
10
1
1
1
Host
Rabbit
62
25
3
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
68
28
20
17
14
7
6
6
3
2
1
1
1
Supplier
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Immunogen A synthetic peptide derived from the C-terminus of survivin
Specificity This antibody detects Survivin.
Purification Protein A chromatography
Alternative Name IAP4 / BIRC5 (BIRC5 Antibody Abstract)
Background Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's antiapoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin
Gene ID 332
NCBI Accession NP_001012270
UniProt O15392
Research Area Cancer, Apoptosis/Necrosis, Neurology
Pathways Apoptosis, Cell Division Cycle
Application Notes Immunohistology (formalin/paraffin): at 1: 500 for 30 min at RT, staining of formalin-fixedtissues REQUIRES boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minfollowed by cooling at RT for 20 min. Positive Control: Stomach.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer 10 mM PBS, pH 7.4, with 0.2 % BSA & 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer.
Supplier Images
 image for anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody (ABIN181412) anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody
Background publications Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

Lu, Altieri, Tanigawa: "Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas." in: Cancer research, Vol. 58, Issue 9, pp. 1808-12, 1998 (PubMed).

Ambrosini, Adida, Altieri: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, 1997 (PubMed).