Cadherin 1 (CDH1) antibody

Antigen: Cadherin 1 (CDH1)

Synonyms: cdh1, E-cadherin, si:dz180o5.2, dZ71B9.1, si:dz180o5.1, CDH1, uvo, lcam, E-Cad, XBcad, l-cam, xcdh1, cdhc-A, xb-cad, XTCAD-1, c-cadherin, cadherin-1, uvomorulin, XB-cadherin, UVO, CDHE, ECAD, LCAM, Arc-1, CD324, HPT1, CDH16, HPT-1, FLJ26931, MGC138218, MGC142024, cad17, hpt1, cdh16, hpt-1, LI-cadherin, cadherin-17

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN181422

Additional Information

Characteristics: Synonyms: Epithelial cadherin, E-cadherin, Uvomorulin, CAM 120/80, CDH1, CDHE, UVO

Alternative name: CD324 / Cadherin-1

Swiss-Prot: P12830

Immunogen: Recombinant protein encoding human Cadherin-E 600-707 aaRemarks: Mol. Wt. of Antigen: 120 kDa

Description: Description: E-cadherin (uvomorulin, Cell-CAM120/80) is a calcium dependent celladhesion molecule expressed predominately in epithelial tissues. It plays an importantrole in the growth and development of cells via the mechanisms of control of tissuearchitecture and the maintenance of tissue integrity. Numerous studies havedemonstrated that reduction and/or loss of E-cadherin expression in carcinomascorrelates positively with the potential of these tumors for invasion and metastasis.

Specificity: This antibody detects Cadherin-E. Species: Human. Others not tested. Add. Information: Cellular Localization: Cell membrane

Synonyms: cdh1, E-cadherin, si:dz180o5.2, dZ71B9.1, si:dz180o5.1, CDH1, uvo, lcam, E-Cad, XBcad, l-cam, xcdh1, cdhc-A, xb-cad, XTCAD-1, c-cadherin, cadherin-1, uvomorulin, XB-cadherin, UVO, CDHE, ECAD, LCAM, Arc-1, CD324, HPT1, CDH16, HPT-1, FLJ26931, MGC138218, MGC142024, cad17, hpt1, cdh16, hpt-1, LI-cadherin, cadherin-17

Application Details

Application Notes: Immunohistology (Formalin/paraffin): 1: 30 for 30 min, staining of formalin-fixed tissuesrequires boiling tissue sections in 10 mM citrate buffer, pH 6.0 for 10-20 min followed bycooling at RT for 20 min. Positive Control: Skin. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.2 mg/ml

Buffer: 10 mM PBS, pH 7.6, with 0.2 % BSA and 15 mM sodium azide.

Storage: Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Extracellular Matrix, Signaling, Cytoskeleton

Restrictions: For Research Use only

Images

Formalin-fixed, paraffin-embedded human skin stained with Cadherin-E (ABIN181422) using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of epithelial cells in sweat glands.