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IL-2 antibody

IL2 Reactivity: Chicken, Mammalian, Avian EIA, Func Host: Mouse Monoclonal 4F12 unconjugated
Catalog No. ABIN181831
  • Target See all IL-2 (IL2) Antibodies
    IL-2 (IL2) (Interleukin 2 (IL2))
    Reactivity
    • 128
    • 89
    • 42
    • 13
    • 9
    • 8
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Chicken, Mammalian, Avian
    Host
    • 111
    • 78
    • 59
    • 10
    • 4
    • 2
    • 1
    Mouse
    Clonality
    • 137
    • 124
    • 1
    Monoclonal
    Conjugate
    • 144
    • 37
    • 23
    • 22
    • 14
    • 9
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL-2 antibody is un-conjugated
    Application
    • 156
    • 123
    • 69
    • 63
    • 40
    • 28
    • 24
    • 21
    • 14
    • 14
    • 13
    • 13
    • 12
    • 11
    • 11
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Enzyme Immunoassay (EIA), Functional Studies (Func)
    Specificity
    This antibody SM1540A recognises natural and recombinant IL-2 expressed in either E.coli or CHO cells. Clone 4F12 neutralises the proliferative activity of rchIL-2 and recognises a different epitope to Clone 10E7 product code (Cat.-No SM1539A). This antibody can be used as the Neutralising antibody for recombinant Chicken IL-2 bioassays (See Product code SA028).
    Purification
    Affinity Chromatography on Protein G
    Immunogen
    Recombinant Chicken IL-2. Remarks: Spleen cells from immunised mice were fused with cells of the mouse Sp2/0-Ag myeloma cell line.
    Clone
    4F12
    Isotype
    IgG2a
    Top Product
    Discover our top product IL2 Primary Antibody
  • Application Notes
    ELISA: 5-10g as capture antibody. Western Blot: Non-reducing conditions. Functional Assays: 2-20g/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS without preservatives, None
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
  • Target
    IL-2 (IL2) (Interleukin 2 (IL2))
    Alternative Name
    Interleukin-2 / IL2 (IL2 Products)
    Synonyms
    IL2 antibody, IL-2 antibody, il2 antibody, TCGF antibody, lymphokine antibody, Il-2 antibody, POIL2 antibody, interleukin 2 antibody, interleukin-15 antibody, IL2 antibody, il2 antibody, LOC100303688 antibody, Il2 antibody
    Background
    Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.Synonyms: IL-2, T-cell growth factor, TCGF
    Gene ID
    3558
    NCBI Accession
    NP_000577
    UniProt
    P60568
    Pathways
    JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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