Lipoprotein Lipase antibody (AA 380-410)

Catalog No. ABIN1820143

Product Details anti-Lipoprotein Lipase Antibody

Target: Lipoprotein Lipase (LPL)

Binding Specificity: AA 380-410

Reactivity: Human, Rat, Cow, Pig, Guinea Pig, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lipoprotein Lipase antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Functional Studies (Func)

Specificity: Recognizes an epitope within amino acids 380-410 of lipoprotein lipase (LPL), a member of the AB hydrolase superfamily, which plays a pivotal role in lipoprotein metabolism and transport, acting as the key enzyme in the hydrolysis of triglycerides and very low density lipoproteins (VLDLs), and the release of free fatty acids into peripheral tissues. A deficiency of LPL can result in hypertriglyceridemia, and many studies have focused on the critical role which LPL plays in the pathogenesis of atherosclerosis, and in particular the relationship between LPL and apolipoprotein E (ApoE), both of which are secreted in significant amounts by macrophages in developing arterial wall lesions. Clone 5D2 is a unique antibody which differentiates between monomeric inactive and dimeric active LPL, and binds to LPL sequences involved in LPL, LPL receptor, and heparin interactions. Clone 5D2 has been shown to inhibit the activity of human LPL(2,3), and is widely used in human studies.

No Cross-Reactivity: Mouse (Murine)

Purification: Protein G purified

Endotoxin Level: Low Endotoxin

Immunogen: Purified bovine milk lipoprotein lipase.

Type of Immunogen: Purified protein

Clone: 5D2

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA (1:500 - 1:5000), Func, IP, WB

Usage: The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Bovine

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for Lipoprotein Lipase

Target: Lipoprotein Lipase (LPL)

Alternative Name: Lipoprotein Lipase / LPL (LPL Products)

Synonyms: HDLCQ11 antibody, LIPD antibody, fb62e04 antibody, fc49b03 antibody, wu:fb62e04 antibody, wu:fc49b03 antibody, LPL antibody, lipd antibody, hdlcq11 antibody, lpl antibody, LOC100223817 antibody, lipoprotein lipase antibody, LPL antibody, Lpl antibody, lpl antibody

Background: Name/Gene ID: LPL

Synonyms: LPL, LIPD, Lipoprotein lipase, HDLCQ11

Gene ID: 4023

Pathways: Lipid Metabolism