Hepatocyte Nuclear Factor 4, alpha (HNF4A) (N-Term) antibody

Details for Product No. ABIN182453
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Antigen
Synonyms
HNF4A, HNF4alpha, CG9310, DmHNF4, Dmel\\CG9310, HNF-4, HNF-4(D), HNF4, Hnf-4, Hnf-4h, NR2A4, dHNF-4, dHNF4, Hnf4, Hnf4alpha, MODY1, Nr2a1, Tcf14, HNF4a7, HNF4a8, HNF4a9, MODY, NR2A1, NR2A21, TCF, TCF1 ... show more
HNF4A, HNF4alpha, CG9310, DmHNF4, Dmel\\CG9310, HNF-4, HNF-4(D), HNF4, Hnf-4, Hnf-4h, NR2A4, dHNF-4, dHNF4, Hnf4, Hnf4alpha, MODY1, Nr2a1, Tcf14, HNF4a7, HNF4a8, HNF4a9, MODY, NR2A1, NR2A21, TCF, TCF14, HNF-4alpha, fb58h09, id:ibd1279, wu:fb58h09, hnf4, nr2a1 show less
Epitope
N-Term
(22), (18), (10), (9), (8), (6), (6), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(127), (61), (60), (28), (26), (25), (24), (4), (1), (1)
Host
Rabbit
(105), (20), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(111), (56), (25), (23), (20), (15), (13), (4), (3), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 50 µg
Options
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Catalog No. ABIN182453
289.00 $
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Immunogen The immunogen for Anti-HNF4A antibody is: synthetic peptide directed towards the N-terminal region of Human HNF4A
Sequence MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Sheep : 100 %, Zebrafish : 90 %, African clawed frog : 80 %
Characteristics This is a rabbit polyclonal antibody against HNF4A. It was validated on Western Blot.
Purification Affinity Purified
Alternative Name HNF4A
Background The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
Molecular Weight 53 kDa
Gene ID 3172
NCBI Accession NP_000448, NM_000457
UniProt P41235
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 474 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (N-Term) antibody WB Suggested Anti-HNF4A Antibody Titration: 0.2-1 ug/ml
Positive Control: Human Liver
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (N-Term) antibody (2) Host: Rabbit
Target Name: HNF4A
Sample Tissue: Human Adult Placenta
Antibody Dilution: 1.0 µg/mL
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (N-Term) antibody (3) Host: Rabbit
Target Name: HNF4A
Sample Tissue: Human Fetal Heart
Antibody Dilution: 1.0 µg/mL
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (N-Term) antibody (4) Host: Rabbit
Target Name: HNF4A
Sample Tissue: Human Fetal Liver
Antibody Dilution: 1.0 µg/mL
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (N-Term) antibody (5) Host: Rabbit
Target Name: HNF4A
Sample Tissue: Human Fetal Lung
Antibody Dilution: 1.0 µg/mL
Product cited in: Weedon, Owen, Shields et al.: "Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population." in: Diabetes, Vol. 53, Issue 11, pp. 3002-6, 2004 (PubMed).

Schmidt, Wilson, Ballester et al.: "Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding." in: Science (New York, N.Y.), Vol. 328, Issue 5981, pp. 1036-40, 2010 (PubMed).

Validation Images
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