E2F Transcription Factor 6 (E2F6) (Middle Region) antibody

Details for Product No. ABIN182510
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Synonyms E2F-6, AI462434, E2F6b, EMA
Middle Region
(13), (9), (8), (6), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(72), (25), (24), (6), (5), (1)
(46), (14), (13)
(1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(65), (36), (21), (10), (6), (6), (5), (4), (3), (3), (1)
Pubmed 2 references available
Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide directed towards the middle region of human E2F6
Predicted Reactivity Dog : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Bovine : 90 %, Guinea pig : 80 %
Characteristics This is a rabbit polyclonal antibody against E2F6. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name E2F6 (E2F6 Antibody Abstract)
Background E2F6 is a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants encoding several different isoforms have been found for this gene.
Molecular Weight 14 kDa
Gene ID 1876
NCBI Accession NP_997705, NM_212540
UniProt Q6Q9Z5
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 129 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-E2F Transcription Factor 6 (E2F6) (Middle Region) antibody (ABIN182510) anti-E2F Transcription Factor 6 (E2F6) (Middle Region) antibody
Product cited in: Lazrek, Goffard, Schanen et al.: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, 2006 (PubMed).

Background publications Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Catalog No. ABIN182510
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