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OTX2 antibody (N-Term)

OTX2 Reactivity: Human, Rat, Mouse, Zebrafish (Danio rerio), Rabbit, Cow, Sheep, Dog, Horse, Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN182571
  • Target See all OTX2 Antibodies
    OTX2 (Orthodenticle Homeobox 2 (OTX2))
    Binding Specificity
    • 15
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 39
    • 29
    • 15
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Zebrafish (Danio rerio), Rabbit, Cow, Sheep, Dog, Horse, Guinea Pig
    Host
    • 52
    • 3
    Rabbit
    Clonality
    • 51
    • 4
    Polyclonal
    Conjugate
    • 28
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This OTX2 antibody is un-conjugated
    Application
    • 39
    • 19
    • 13
    • 13
    • 12
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    PESRVQVWFK NRRAKCRQQQ QQQQNGGQNK VRPAKKKTSP AREVSSESGT
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against OTX2. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human OTX2
    Top Product
    Discover our top product OTX2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 297 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Machali?ska, Kawa, Pius-Sadowska, Rogi?ska, K?os, Baumert, Wiszniewska, Machali?ski: "Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: an insight into the role of glial cells in retinal repair." in: Experimental eye research, Vol. 112, pp. 68-78, (2013) (PubMed).

    Aluigi, Angelini, Corte, Falugi: "The sea urchin, Paracentrotus lividus, embryo as a "bioethical" model for neurodevelopmental toxicity testing: effects of diazinon on the intracellular distribution of OTX2-like proteins." in: Cell biology and toxicology, Vol. 24, Issue 6, pp. 587-601, (2008) (PubMed).

    Takeda, Yokoyama, Yasumoto, Saito, Udono, Takahashi, Shibahara: "OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium." in: Biochemical and biophysical research communications, Vol. 300, Issue 4, pp. 908-14, (2003) (PubMed).

  • Target
    OTX2 (Orthodenticle Homeobox 2 (OTX2))
    Alternative Name
    OTX2 (OTX2 Products)
    Synonyms
    CPHD6 antibody, MCOPS5 antibody, E130306E05Rik antibody, id:ibd2915 antibody, zOtx2 antibody, zgc:136535 antibody, zotx-2 antibody, Xotx-2 antibody, Xotx2 antibody, otx-2 antibody, otx2 antibody, orthodenticle homeobox 2 antibody, orthodenticle homeobox 2 S homeolog antibody, orthodenticle homeobox 2 L homeolog antibody, OTX2 antibody, Otx2 antibody, otx2 antibody, otx2.S antibody, otx2.L antibody
    Background
    Homeobox protein OTX2 is a member of the bicoid sub-family of homeodomain-containing transcription factors. This protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined. This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.
    Alias Symbols: MCOPS5, MGC45000, CPHD6
    Protein Interaction Partner: ATXN1, CDK4, APP, DMBX1, TLE4, FOXA2, MITF, OTX2, LHX1,
    Protein Size: 297
    Molecular Weight
    32 kDa
    Gene ID
    5015
    NCBI Accession
    NM_021728, NP_068374
    Pathways
    Dopaminergic Neurogenesis
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