Paired Box 3 (PAX3) (Middle Region) antibody

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Antigen
Epitope
Middle Region
(36), (12), (8), (7), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(100), (30), (21), (9), (6), (5), (3), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(56), (28), (21)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (3), (3), (3), (3), (1)
Application
Western Blotting (WB)
(84), (51), (29), (13), (7), (4), (4), (3), (3), (3), (2), (1), (1)
Pubmed 1 reference available
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Quantity 100 μg
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Immunogen Synthetic peptide directed towards the middle region of human PAX3
Sequence KGEEEEADLE RKEAEESEKK AKHSIDGILS ERASAPQSDE GSDIDSEPDL
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Goat : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, Chicken : 90 %
Characteristics This is a rabbit polyclonal antibody against PAX3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name PAX3 (PAX3 Antibody Abstract)
Background PAX3 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma.
Molecular Weight 45 kDa
Gene ID 5077
NCBI Accession NP_852126, NM_181461
UniProt Q86UQ3
Research Area Organogenesis, Lineage Markers, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 403 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Paired Box 3 (PAX3) (Middle Region) antibody (ABIN182574) anti-Paired Box 3 (PAX3) (Middle Region) antibody
Background publications Wachtel, Dettling, Koscielniak et al.: "Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1." in: Cancer research, Vol. 64, Issue 16, pp. 5539-45, 2004 (PubMed).

Catalog No. ABIN182574
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