Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16) (N-Term) antibody

Details for Product No. ABIN182872
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Antigen
Synonyms PARP16, zgc:77744, ARTD15, C15orf30, pART15, BC055447, C79952, PARP-16, LRRGT00109, RGD1306243
Epitope
N-Term
(8), (7), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Human
(39), (13), (13), (13), (12)
Host
Rabbit
(30), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(22), (17), (10), (8), (8), (4), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN182872
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human PARP16
Sequence KRDSVLRPFP ASYARGDCKD FEALLADASK LPNLKELLQS SGDNHKRAWD
Predicted Reactivity Bovine : 100 %, Horse : 100 %, Mouse : 100 %, Rat : 100 %, Dog : 90 %, Rabbit : 90 %, Guinea pig : 80 %
Characteristics This is a rabbit polyclonal antibody against PARP16. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PARP16
Background Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP16 is a member of poly(ADP-ribose) polymerases (PARPs) family that is encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
Molecular Weight 36 kDa
Gene ID 54956
NCBI Accession NP_060321, NM_017851
UniProt Q6PK64
Research Area Chromatin and Nuclear Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 323 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

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