anti-Tryptophan Hydroxylase 2 antibody (TPH2) (N-Term)

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Antigen
Synonyms tph2, tph1l, tphD2, ADHD7, NTPH, AU043594, Ntph, tphR, wu:fq15a04
Epitope
N-Term
(31), (28), (15), (13), (13), (11), (10), (6), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(96), (53), (47), (9), (8), (4), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(83), (39), (1)
Clonality
Polyclonal
Conjugate
This Tryptophan Hydroxylase 2 antibody is un-conjugated
(6), (5), (5), (5), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(86), (68), (37), (14), (12), (10), (3), (3), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human TPH2
Blocking Peptide Blocking peptide for this product available: Tryptophan Hydroxylase 2 (TPH2) peptide (ABIN985410)
Sequence REAATESGKT AVVFSLKNEV GGLVKALRLF QEKRVNMVHI ESRKSRRRSS
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Human : 100 %, Rabbit : 100 %, Mouse : 90 %, Chicken : 90 %, Rat : 90 %, Horse : 80 %
Characteristics This is a rabbit polyclonal antibody against TPH2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TPH2 (TPH2 Antibody Abstract)
Background Tryptophan hydroxylase (TPH, EC 1.14.16.4) is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility.
Molecular Weight 56 kDa
Gene ID 121278
NCBI Accession NP_775489, NM_173353
UniProt Q8IWU9
Research Area Neurology, Metabolism
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 490 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Tryptophan Hydroxylase 2 antibody (TPH2) (N-Term) (ABIN182938) WB Suggested Anti-TPH2 Antibody Titration: 0.2-1 ug/ml
Positive Control:...
Product cited in: Walther, Peter, Bashammakh et al.: "Synthesis of serotonin by a second tryptophan hydroxylase isoform." in: Science (New York, N.Y.), Vol. 299, Issue 5603, pp. 76, 2003 (PubMed).

Catalog No. ABIN182938
$289.00
Plus shipping costs $45.00

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