Death Inducer-Obliterator 1 (DIDO1) (N-Term) antibody

Details for Product No. ABIN183106
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Antigen
Synonyms
DIDO1, DKFZp469J1523, bye1, dio1, datf1, dido2, dido3, dio-1, BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8, 6720461J16Rik, C530043I07, D130048F08Rik, Datf1, Dido2, Dido3, mKIAA ... show more
DIDO1, DKFZp469J1523, bye1, dio1, datf1, dido2, dido3, dio-1, BYE1, C20orf158, DATF-1, DATF1, DIDO2, DIDO3, DIO-1, DIO1, dJ885L7.8, 6720461J16Rik, C530043I07, D130048F08Rik, Datf1, Dido2, Dido3, mKIAA0333, datf1l, fi35b04, wu:fi35b04, zgc:158157, 5DI, TXDI1 show less
Epitope
N-Term
(9), (3), (2), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Human, Chicken
(40), (27), (15), (2), (2), (2), (1), (1)
Host
Rabbit
(36), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(29), (14), (9), (4), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN183106
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human DIDO1
Sequence ERVEQFLTIA RRRGRRSMPV SLEDSGEPTS CPATDAETAS EGSVESASET
Predicted Reactivity Human : 100 %, Rabbit : 100 %, Bovine : 90 %, Chicken : 90 %, Horse : 90 %, Mouse : 90 %, Rat : 90 %, Guinea pig : 80 %
Characteristics This is a rabbit polyclonal antibody against DIDO1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name DIDO1
Background In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. DIDO1 gene is similar to the mouse gene and therefore is thought to be involved in apoptosis.Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.
Molecular Weight 59 kDa
Gene ID 11083
NCBI Accession NP_542987, NM_080797
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 544 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Death Inducer-Obliterator 1 (DIDO1) (N-Term) antibody WB Suggested Anti-DIDO1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate
anti-Death Inducer-Obliterator 1 (DIDO1) (N-Term) antibody (2) WB Suggested Anti-DIDO1
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500
Positive Control: Jurkat cell lysate
DIDO1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
Background publications Fütterer, Campanero, Leonardo et al.: "Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms." in: The Journal of clinical investigation, Vol. 115, Issue 9, pp. 2351-62, 2005 (PubMed).

Validation Images
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