Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) (C-Term) antibody

Details for Product No. ABIN183174
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Antigen
Synonyms KCa2.3, SK3, SKCA3, hSK3
Epitope
C-Term
(3), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Pig (Porcine), Dog (Canine), Human
(19), (16), (15), (13), (13), (13), (12)
Host
Rabbit
(19), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(12), (10), (4), (3), (2), (1)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN183174
229.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human KCNN3
Sequence DRSEDLEKQI GSLESKLEHL TASFNSLPLL IADTLRQQQQ QLLSAIIEAR
Predicted Reactivity Bovine : 100 %, Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, Rabbit : 80 %, Dog : 70 %
Characteristics This is a rabbit polyclonal antibody against KCNN3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name KCNN3
Background Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by KCNN3 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN3 contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions.
Molecular Weight 47 kDa
Gene ID 3782
NCBI Accession NP_740752, NM_170782
UniProt Q8WXG7
Research Area Neurology
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 426 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) (C-Term) antibody WB Suggested Anti-KCNN3 Antibody Titration: 2.5ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate
Background publications Kolski-Andreaco, Tomita, Shakkottai et al.: "SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels." in: The Journal of biological chemistry, Vol. 279, Issue 8, pp. 6893-904, 2004 (PubMed).

Validation Images
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