Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) (N-Term) antibody

Details for Product No. ABIN183177
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Antigen
Epitope
N-Term
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Dog (Canine), Zebrafish (Danio rerio), Cow (Bovine), Human, Chicken
Host
Rabbit
Clonality
Polyclonal
Application
Western Blotting (WB)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN183177
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Immunogen Synthetic peptide directed towards the N terminal of human KCNQ2
Sequence YRGWRGRLKF ARKPFCVIDI MVLIASIAVL AAGSQGNVFA TSALRSLRFL
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Zebrafish : 90 %
Characteristics This is a rabbit polyclonal antibody against KCNQ2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name KCNQ2
Background The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by KCNQ2 and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).
Molecular Weight 93 kDa
Gene ID 3785
NCBI Accession NM_004518, NP_004509
UniProt Q5VYT9
Research Area Neurology
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 844 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) (N-Term) antibody WB Suggested Anti-KCNQ2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: HepG2 cell lysate
Product cited in: Tang, Li, Xia et al.: "A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family." in: Journal of the neurological sciences, Vol. 221, Issue 1-2, pp. 31-4, 2004 (PubMed).

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