Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) antibody
| Antigen |
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| Synonyms |
EBN, BFNC, EBN1, ENB1, HNSPC, KV7.2, KCNA11, KVEBN1 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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 Alternatives Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken, Rabbit, Zebrafish
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Conjugate
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Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
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Application
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Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
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| Catalog no. |
ABIN183178 |
| Quantity |
0.1 mg (Variants) |
| Price |
251.90 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Alternative name
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KCNQ2
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Gene ID
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KCNQ2
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UniProt
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Q5VYU0
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Immunogen
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The immunogen for anti-KCNQ2 antibody: synthetic peptide directed towards the middle region of human KCNQ2
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Sequence
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GNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAH SKELVTAWYI
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Cross-Reactivity
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Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rabbit, Rat (Rattus)
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Format
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Lyophilized
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Reconstitution
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Add 100 µl of distilled water. Final anti-KCNQ2 antibody concentration is 1 mg/ml.
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Description
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The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).
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Characteristics
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Antigen Size: 393 amino acids
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Molecular Weight
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43kDa
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Application Notes
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WB Suggested Anti-KCNQ2 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:62500
Positive Control: HepG2 cell lysate.
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Purification
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Protein A purified
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Buffer
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PBS
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Storage (Long Term)
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For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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Storage (Short Term)
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Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.
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Research Area
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Neurology
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Restrictions
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For Research Use only
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Product
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Tang, Li, Xia et al.: "A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family." in: Journal of the neurological sciences, Vol. 221, Issue 1-2, pp. 31-4, 2004 (PubMed).
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Alternatives for antigen "Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2)", type "Antibodies"
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Hosts
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Rabbit (39), Mouse (7)
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Reactivities
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Human (38), Mouse (Murine) (28), Rat (Rattus) (26), Dog (Canine) (20), Cow (Bovine) (19), Horse (Equine) (18), Sheep (Ovine) (18), Chicken (3), Rabbit (3), Zebrafish (3)
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Applications
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Western Blotting (WB) (28), Immunofluorescence (IF) (18), Immunohistochemistry (IHC) (17), ELISA (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunoprecipitation (IP) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunocytochemistry (ICC) (2), Immunostaining (ISt) (2), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
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Epitopes
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Internal Region (4), N-Term (4), AA 1-59 (3), Center (1)
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2013 BioMed Central Research Awards
